Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2462446..2463098 Replicon chromosome
Accession NZ_AP024545
Organism Lysobacter caseinilyticus strain JCM32879

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LYSCAS_RS11940 Protein ID WP_213437897.1
Coordinates 2462895..2463098 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LYSCAS_RS11935 Protein ID WP_213434256.1
Coordinates 2462446..2462880 (-) Length 145 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LYSCAS_RS11915 (LYSCAS_23490) 2457662..2458828 + 1167 WP_213434253.1 glycosyltransferase family 4 protein -
LYSCAS_RS11920 (LYSCAS_23500) 2458833..2459594 + 762 WP_213434254.1 YdcF family protein -
LYSCAS_RS11925 (LYSCAS_23510) 2459799..2460872 + 1074 WP_244858535.1 polysaccharide biosynthesis/export family protein -
LYSCAS_RS11930 (LYSCAS_23520) 2461014..2462438 + 1425 WP_213434255.1 DNA repair protein RadA -
LYSCAS_RS11935 (LYSCAS_23530) 2462446..2462880 - 435 WP_213434256.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LYSCAS_RS11940 (LYSCAS_23540) 2462895..2463098 - 204 WP_213437897.1 hypothetical protein Toxin
LYSCAS_RS11945 (LYSCAS_23550) 2463244..2464815 - 1572 WP_213434257.1 DHA2 family efflux MFS transporter permease subunit -
LYSCAS_RS11950 (LYSCAS_23560) 2464834..2466012 - 1179 WP_213434258.1 efflux RND transporter periplasmic adaptor subunit -
LYSCAS_RS11955 (LYSCAS_23570) 2466028..2467485 - 1458 WP_213434259.1 efflux transporter outer membrane subunit -
LYSCAS_RS11960 (LYSCAS_23580) 2467487..2467930 - 444 WP_213434260.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7749.01 Da        Isoelectric Point: 11.1552

>T38613 WP_213437897.1 NZ_AP024545:c2463098-2462895 [Lysobacter caseinilyticus]
MDAGFHGAMDMKQCEFRRWLALRGALFKEGSKHTRVYYRGRQSTLPRHPAHEIGEALRKAIIRQPGL

Download         Length: 204 bp

>T38613 NZ_AP024545:c2463098-2462895 [Lysobacter caseinilyticus]
ATGGACGCCGGTTTCCACGGCGCCATGGACATGAAGCAGTGCGAATTCCGCCGGTGGCTCGCATTGCGCGGCGCGTTGTT
CAAGGAAGGCAGCAAGCACACGCGCGTGTACTACCGCGGCCGGCAGAGCACCCTGCCCCGGCATCCGGCGCACGAGATCG
GTGAAGCGCTGCGCAAGGCGATCATCCGCCAACCCGGCCTCTGA

Antitoxin


Download         Length: 145 a.a.        Molecular weight: 16275.75 Da        Isoelectric Point: 7.2054

>AT38613 WP_213434256.1 NZ_AP024545:c2462880-2462446 [Lysobacter caseinilyticus]
MLVYPVTIERDGKGWFVRFDDIPEALTSGRSRAHALSMAQDALESAMEFYFQDRRPVPLPGKAKPGQDTVELPASLSAKV
LLLNEMLVQGITPAELARRLDTTPQSVQRIIDLDHVTKIDTIAQAFRVMDRRLDFQVKRWPQSA

Download         Length: 435 bp

>AT38613 NZ_AP024545:c2462880-2462446 [Lysobacter caseinilyticus]
ATGCTGGTCTACCCCGTCACGATCGAACGCGATGGCAAGGGATGGTTCGTGCGTTTCGACGACATCCCCGAAGCGCTCAC
CTCCGGGCGTTCGCGCGCGCATGCGCTGTCGATGGCGCAGGACGCGCTCGAGAGCGCGATGGAGTTCTACTTCCAGGATC
GCCGTCCGGTGCCGTTGCCGGGCAAGGCGAAGCCGGGCCAGGACACGGTCGAACTGCCCGCCTCGCTCAGCGCCAAGGTG
CTGCTGCTCAACGAAATGCTGGTGCAGGGCATCACGCCGGCGGAACTCGCCCGCCGCCTCGACACCACGCCGCAATCCGT
GCAGCGCATCATCGACCTGGACCACGTCACCAAGATCGACACCATCGCGCAGGCGTTCCGCGTGATGGACCGGCGGCTGG
ATTTCCAGGTGAAGCGTTGGCCGCAATCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References