Detailed information of TA system TA038612

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 1156346..1156866
• Replicon: chromosome
• Accession: NZ_AP024525
• Organism: Corynebacterium cyclohexanicum strain ATCC 51369

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: SCMU_RS05435
• Protein ID: WP_229232013.1
• Coordinates: 1156346..1156636 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: SCMU_RS05440
• Protein ID: WP_229232014.1
• Coordinates: 1156633..1156866 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SCMU_RS05420 (SCMU_10880)	1151706..1152329	+	624	WP_229232010.1	Ltp family lipoprotein	-
SCMU_RS05425 (SCMU_10890)	1152685..1153911	+	1227	WP_229232011.1	exonuclease domain-containing protein	-
SCMU_RS05430 (SCMU_10910)	1154422..1156272	-	1851	WP_229232012.1	hypothetical protein	-
SCMU_RS05435 (SCMU_10920)	1156346..1156636	-	291	WP_229232013.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SCMU_RS05440 (SCMU_10930)	1156633..1156866	-	234	WP_229232014.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
SCMU_RS05445 (SCMU_10940)	1157032..1159344	+	2313	WP_229232015.1	AAA domain-containing protein	-
SCMU_RS05450 (SCMU_10950)	1159355..1159837	+	483	WP_229232016.1	DUF2726 domain-containing protein	-
SCMU_RS05455 (SCMU_10960)	1160018..1161220	+	1203	WP_229232017.1	Fic family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (1-77)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11237.67 Da
• Isoelectric Point: 7.2748

>T38612 WP_229232013.1 NZ_AP024525:c1156636-1156346 [Corynebacterium cyclohexanicum]
VKQYRLTPAAVQDLSSIWDYTADRWGPGQAEMYVGELRNAIERVADRPDRGRPCDEIRAGYRRYAIGSHLIFYLETDTTV
DVIRILHQRMDPTRHF

Nucleotide

• Length: 291 bp

>T38612 NZ_AP024525:c1156636-1156346 [Corynebacterium cyclohexanicum]
GTGAAGCAGTACCGGCTCACGCCGGCCGCGGTACAGGACCTCTCATCCATCTGGGACTACACAGCCGACCGCTGGGGTCC
CGGCCAGGCCGAGATGTACGTGGGAGAGCTGCGCAACGCGATCGAACGGGTCGCGGACCGCCCCGATCGTGGCCGCCCCT
GCGACGAAATCCGTGCCGGGTACCGGCGCTACGCGATCGGCAGCCACCTGATCTTCTACCTCGAGACCGATACAACGGTC
GACGTGATCCGCATCCTGCACCAGCGCATGGACCCTACCCGGCACTTCTAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8330.26 Da
• Isoelectric Point: 5.0790

>AT38612 WP_229232014.1 NZ_AP024525:c1156866-1156633 [Corynebacterium cyclohexanicum]
MARNTSISLDAHFSAFLAREVATGRYGSASEVVRAGLRLLEDQEARLSALRSALSAGEASGEPEPFDFDAFVAEKRR

Nucleotide

• Length: 234 bp

>AT38612 NZ_AP024525:c1156866-1156633 [Corynebacterium cyclohexanicum]
ATGGCGCGCAATACGTCGATCAGCCTGGATGCCCACTTCTCCGCTTTCCTCGCCCGCGAGGTCGCGACGGGCCGCTACGG
GTCCGCGAGCGAGGTCGTGCGTGCCGGCCTCCGGCTTCTGGAGGATCAGGAGGCCCGGCTCTCCGCGCTGCGCTCAGCCC
TGAGTGCGGGCGAGGCCAGCGGCGAGCCGGAGCCCTTCGACTTCGACGCGTTCGTGGCCGAGAAGCGCCGGTGA