Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 511915..512551 Replicon chromosome
Accession NZ_AP024524
Organism Acinetobacter variabilis strain RYU24

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag I0P84_RS02455 Protein ID WP_214001897.1
Coordinates 512165..512551 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag I0P84_RS02450 Protein ID WP_125278962.1
Coordinates 511915..512172 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I0P84_RS02430 (RYU24_04750) 507406..508413 + 1008 WP_004786889.1 DNA-directed RNA polymerase subunit alpha -
I0P84_RS02435 (RYU24_04760) 508432..508797 + 366 WP_004786886.1 50S ribosomal protein L17 -
I0P84_RS02440 (RYU24_04770) 509017..510507 + 1491 WP_214001895.1 NAD(P)/FAD-dependent oxidoreductase -
I0P84_RS02445 (RYU24_04780) 510560..511732 - 1173 WP_214001896.1 acyl-CoA dehydrogenase family protein -
I0P84_RS02450 (RYU24_04790) 511915..512172 + 258 WP_125278962.1 succinate dehydrogenase assembly factor 2 Antitoxin
I0P84_RS02455 (RYU24_04800) 512165..512551 + 387 WP_214001897.1 hypothetical protein Toxin
I0P84_RS02460 (RYU24_04810) 513098..514138 + 1041 WP_208461939.1 hypothetical protein -
I0P84_RS02465 (RYU24_04820) 514211..514783 + 573 WP_005233757.1 rhombosortase -
I0P84_RS02470 (RYU24_04830) 514961..517243 + 2283 WP_208461938.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-80)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 15218.40 Da        Isoelectric Point: 10.0347

>T38611 WP_214001897.1 NZ_AP024524:512165-512551 [Acinetobacter variabilis]
MDNRCFKLKRSKCALVFQLFIFAVLMFLLYQLLPVIMWLVCGVIGLVIYQLFYRKIPHIEQFEYLDGREWSLTAAAQGTR
RVLISHVIDHQAYIVVYFQHAKARPLLIWCDQLPFKQWKSLKVLTKIL

Download         Length: 387 bp

>T38611 NZ_AP024524:512165-512551 [Acinetobacter variabilis]
ATGGATAATCGCTGTTTTAAGCTGAAACGCAGTAAGTGTGCACTGGTGTTTCAGCTTTTTATTTTCGCTGTATTGATGTT
CTTGCTGTATCAGTTATTGCCTGTAATAATGTGGCTGGTTTGTGGCGTCATCGGTCTGGTCATCTACCAGTTGTTTTATC
GTAAGATACCGCACATTGAGCAGTTTGAATATCTGGATGGACGTGAATGGTCACTGACTGCAGCTGCACAAGGCACACGG
CGAGTGTTGATCAGTCACGTGATTGATCACCAAGCTTATATCGTGGTGTATTTCCAACATGCAAAAGCACGTCCGTTGCT
CATCTGGTGTGATCAGTTACCTTTTAAACAATGGAAGTCTTTGAAAGTTTTAACAAAAATACTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10309.80 Da        Isoelectric Point: 4.4709

>AT38611 WP_125278962.1 NZ_AP024524:511915-512172 [Acinetobacter variabilis]
MTDDITLEERKVIYRARRGLKEIDVYFDPYVKNYYLNADPFEKEMFAELVAQEDPDLLDWFMEVSEPPRPELKDFIKKLK
FYVHG

Download         Length: 258 bp

>AT38611 NZ_AP024524:511915-512172 [Acinetobacter variabilis]
ATGACTGATGACATCACCTTAGAAGAGCGCAAAGTGATTTATCGCGCGCGTCGTGGCTTGAAAGAGATCGATGTATATTT
TGATCCCTACGTGAAAAACTATTATCTCAATGCTGATCCCTTCGAAAAAGAGATGTTTGCTGAGCTGGTTGCACAGGAAG
ATCCGGACCTGCTGGACTGGTTTATGGAAGTGTCAGAACCCCCACGCCCTGAATTAAAAGATTTTATCAAGAAGCTTAAA
TTTTACGTTCATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References