Detailed information of TA system TA038610

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1191038..1191536
• Replicon: chromosome
• Accession: NZ_AP024523
• Organism: Streptococcus toyakuensis strain TP1632

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: STYK_RS06150
• Protein ID: WP_191962389.1
• Coordinates: 1191038..1191292 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F9HDX8
• Locus tag: STYK_RS06155
• Protein ID: WP_000208079.1
• Coordinates: 1191294..1191536 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
STYK_RS06135 (STYK_11610)	1188004..1189722	+	1719	WP_261804712.1	phospho-sugar mutase	-
STYK_RS06140 (STYK_11620)	1189834..1190181	+	348	WP_023944304.1	thioredoxin	-
STYK_RS06145 (STYK_11630)	1190219..1190992	-	774	WP_261804713.1	ion channel	-
STYK_RS06150 (STYK_11640)	1191038..1191292	-	255	WP_191962389.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
STYK_RS06155 (STYK_11650)	1191294..1191536	-	243	WP_000208079.1	DUF6290 family protein	Antitoxin
STYK_RS06160 (STYK_11660)	1191627..1192436	-	810	WP_004254224.1	MBL fold metallo-hydrolase	-
STYK_RS06165 (STYK_11670)	1192429..1193787	-	1359	WP_261804714.1	cell wall metabolism sensor histidine kinase VicK	-
STYK_RS06170 (STYK_11680)	1193780..1194487	-	708	WP_000722071.1	response regulator YycF	-
STYK_RS06175 (STYK_11690)	1194542..1195717	-	1176	WP_261804715.1	A/G-specific adenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10098.79 Da
• Isoelectric Point: 10.7632

>T38610 WP_191962389.1 NZ_AP024523:c1191292-1191038 [Streptococcus toyakuensis]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDEVVIATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T38610 NZ_AP024523:c1191292-1191038 [Streptococcus toyakuensis]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGATCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCGAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAAGTAGTCATTGCTACTTTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9206.40 Da
• Isoelectric Point: 3.9338

>AT38610 WP_000208079.1 NZ_AP024523:c1191536-1191294 [Streptococcus toyakuensis]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLEDE

Nucleotide

• Length: 243 bp

>AT38610 NZ_AP024523:c1191536-1191294 [Streptococcus toyakuensis]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
GTCGGAACTTATCCGCACCAAAACTCTTGAAGCTCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGGAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: F9HDX8