Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 567774..568401 Replicon chromosome
Accession NZ_AP024523
Organism Streptococcus toyakuensis strain TP1632

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag STYK_RS03100 Protein ID WP_261805214.1
Coordinates 568051..568401 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag STYK_RS03095 Protein ID WP_261805213.1
Coordinates 567774..568061 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STYK_RS03080 (STYK_05530) 564686..565789 + 1104 WP_000241736.1 Gfo/Idh/MocA family oxidoreductase -
STYK_RS03085 (STYK_05540) 565858..566775 + 918 WP_261805211.1 dihydrodipicolinate synthase family protein -
STYK_RS03090 (STYK_05550) 566793..567677 + 885 WP_261805212.1 ROK family protein -
STYK_RS03095 (STYK_05560) 567774..568061 + 288 WP_261805213.1 hypothetical protein Antitoxin
STYK_RS03100 (STYK_05570) 568051..568401 + 351 WP_261805214.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
STYK_RS03105 (STYK_05580) 568463..569314 - 852 WP_261805215.1 MurR/RpiR family transcriptional regulator -
STYK_RS03110 (STYK_05590) 569507..571564 + 2058 WP_261805216.1 penicillin-binding protein 2B -
STYK_RS03115 (STYK_05600) 571575..572171 + 597 WP_261805217.1 recombination mediator RecR -
STYK_RS03120 (STYK_05610) 572346..573389 + 1044 WP_261805218.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13789.94 Da        Isoelectric Point: 9.8158

>T38609 WP_261805214.1 NZ_AP024523:568051-568401 [Streptococcus toyakuensis]
MDYKKYRILYSPRVIDSLDKIYQYIAEEIGSVEAARRKVESIRKDINRLEIFPQAGFDADEKFGKKLDPRYQTRGLTLSK
NYIVLYTIVEDTVRLAYLLPSKSDYMKLFKTKSRYE

Download         Length: 351 bp

>T38609 NZ_AP024523:568051-568401 [Streptococcus toyakuensis]
ATGGATTATAAAAAATATAGGATTTTGTATTCTCCTAGAGTGATTGATAGTTTGGATAAAATATATCAGTATATAGCAGA
GGAAATCGGTTCTGTAGAGGCTGCGAGACGAAAAGTGGAGAGTATCAGAAAAGATATTAATCGTCTAGAAATTTTCCCCC
AAGCTGGATTTGATGCCGATGAAAAATTTGGTAAGAAATTAGATCCTCGCTACCAAACGCGAGGATTGACCTTGAGTAAG
AATTACATCGTATTATATACAATTGTTGAGGATACCGTCAGACTTGCTTATTTACTCCCTTCAAAAAGTGATTACATGAA
ATTATTCAAGACTAAATCAAGATATGAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10858.24 Da        Isoelectric Point: 4.1638

>AT38609 WP_261805213.1 NZ_AP024523:567774-568061 [Streptococcus toyakuensis]
MAIADSNKIVTFQANRELVNDAMEVLKEKNLSLSSALRLFLKNVAVTNEVDLLSEEELEREYLFRQLQAEVQESYAKIEA
GNYLTDEDVVTRYGL

Download         Length: 288 bp

>AT38609 NZ_AP024523:567774-568061 [Streptococcus toyakuensis]
ATGGCTATAGCGGATTCAAATAAAATTGTGACCTTCCAAGCTAATAGAGAATTAGTAAATGATGCCATGGAAGTGTTAAA
AGAAAAAAATCTCTCTCTTTCATCGGCACTCAGATTATTTTTAAAGAATGTTGCCGTAACAAATGAAGTAGATTTACTGA
GTGAAGAGGAATTAGAGAGGGAGTATTTGTTTAGACAATTACAAGCAGAAGTTCAAGAAAGTTATGCCAAAATTGAGGCT
GGAAATTACTTGACAGATGAGGATGTCGTGACACGCTATGGATTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References