Detailed information of TA system TA038608

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 110314..110938
• Replicon: chromosome
• Accession: NZ_AP024523
• Organism: Streptococcus toyakuensis strain TP1632

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A139PLM5
• Locus tag: STYK_RS00550
• Protein ID: WP_061439908.1
• Coordinates: 110591..110938 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: STYK_RS00545
• Protein ID: WP_261805044.1
• Coordinates: 110314..110601 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
STYK_RS00520 (STYK_00960)	106101..107268	-	1168	Protein_96	IS30 family transposase	-
STYK_RS00525 (STYK_00980)	107605..108216	+	612	WP_000092756.1	30S ribosomal protein S4	-
STYK_RS00530	108312..108602	-	291	Protein_98	tyrosine-type recombinase/integrase	-
STYK_RS00535 (STYK_00990)	108643..109176	+	534	WP_173214599.1	DUF4065 domain-containing protein	-
STYK_RS00540 (STYK_01000)	109164..110081	+	918	WP_173214597.1	hypothetical protein	-
STYK_RS00545 (STYK_01010)	110314..110601	+	288	WP_261805044.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
STYK_RS00550 (STYK_01020)	110591..110938	+	348	WP_061439908.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
STYK_RS00555 (STYK_01030)	111756..112562	+	807	WP_261805045.1	hypothetical protein	-
STYK_RS00560 (STYK_01040)	112584..113831	+	1248	WP_261805046.1	toxic anion resistance protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	109164..135889	26725

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (10-108)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-62)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13355.23 Da
• Isoelectric Point: 5.6608

>T38608 WP_061439908.1 NZ_AP024523:110591-110938 [Streptococcus toyakuensis]
MEFNENAYSLIISETVQEQLRGIKDYISANYFSEQAGANTVKNILYGLERLEVFPEAGFDADERVGSIIYPPHKTRCIIL
GDYLAFYHILEDRKAVFISDIIHSKQDYIRLFKKK

Nucleotide

• Length: 348 bp

>T38608 NZ_AP024523:110591-110938 [Streptococcus toyakuensis]
TTGGAATTTAACGAGAACGCATATAGCCTTATTATCTCCGAAACGGTACAAGAACAGCTAAGAGGTATTAAAGATTATAT
CTCAGCTAACTACTTTTCAGAACAGGCAGGAGCAAACACAGTTAAGAATATTCTTTATGGTTTGGAGCGTCTTGAAGTCT
TCCCAGAAGCGGGATTTGATGCTGACGAAAGAGTAGGAAGTATTATATACCCACCCCACAAAACTCGATGCATCATTTTA
GGCGATTACCTAGCCTTCTATCATATTTTAGAGGATAGAAAAGCTGTCTTTATATCAGATATTATTCATAGCAAACAGGA
CTACATCCGCTTGTTCAAGAAAAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10851.36 Da
• Isoelectric Point: 4.5686

>AT38608 WP_261805044.1 NZ_AP024523:110314-110601 [Streptococcus toyakuensis]
MNVLEKNTQVNFKTNRDLLEKAKAIITAQNLDMTASFNLFLEHIVENKALPFETQVDKEREELLLGLRAEIACSFEDLEH
GKTYSLDEVRANLGI

Nucleotide

• Length: 288 bp

>AT38608 NZ_AP024523:110314-110601 [Streptococcus toyakuensis]
ATGAATGTTTTAGAAAAAAACACACAGGTAAATTTTAAGACTAACAGAGACTTGTTAGAAAAGGCTAAAGCTATTATCAC
AGCGCAAAATCTTGATATGACAGCCAGTTTTAACTTGTTTTTAGAACACATTGTAGAAAATAAAGCCTTGCCATTTGAAA
CTCAAGTAGACAAAGAAAGAGAAGAACTTCTATTAGGATTGCGTGCCGAAATTGCCTGTAGCTTTGAGGATTTAGAACAT
GGAAAGACTTACAGCCTTGATGAAGTGAGGGCTAACCTTGGAATTTAA

Structures

Toxin

• AlphaFold DB: A0A139PLM5