Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 626282..626919 Replicon chromosome
Accession NZ_AP024513
Organism Pseudomonas aeruginosa isolate Pa12

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KJS76_RS02910 Protein ID WP_019725766.1
Coordinates 626282..626464 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KJS76_RS02915 Protein ID WP_019725767.1
Coordinates 626497..626919 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJS76_RS02890 623263..623406 + 144 WP_152959728.1 hypothetical protein -
KJS76_RS29545 623611..623736 - 126 WP_280516679.1 hypothetical protein -
KJS76_RS02895 623811..624068 - 258 Protein_578 nuclease-related domain-containing protein -
KJS76_RS02900 (RVB2_05800) 624161..625282 - 1122 WP_003113218.1 Fic family protein -
KJS76_RS02905 (RVB2_05810) 625541..625702 - 162 WP_003118892.1 hypothetical protein -
KJS76_RS02910 (RVB2_05820) 626282..626464 + 183 WP_019725766.1 type II toxin-antitoxin system HicA family toxin Toxin
KJS76_RS02915 (RVB2_05830) 626497..626919 + 423 WP_019725767.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KJS76_RS02920 (RVB2_05850) 627165..628136 - 972 WP_058171393.1 hypothetical protein -
KJS76_RS02925 (RVB2_05860) 628121..628813 - 693 WP_058171392.1 hypothetical protein -
KJS76_RS02930 (RVB2_05870) 628810..629352 - 543 WP_025982284.1 hypothetical protein -
KJS76_RS02935 (RVB2_05880) 629349..630272 - 924 WP_031633727.1 hypothetical protein -
KJS76_RS02940 (RVB2_05890) 630269..630745 - 477 WP_058171390.1 phage tail assembly chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 624161..674674 50513


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-62)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6970.07 Da        Isoelectric Point: 10.2954

>T38541 WP_019725766.1 NZ_AP024513:626282-626464 [Pseudomonas aeruginosa]
MKYSEFRRWLKARGVIFEPAKGSHFKVYYGDNQTIFPDHGAKEIGDGLRKKIIKDLGLKD

Download         Length: 183 bp

>T38541 NZ_AP024513:626282-626464 [Pseudomonas aeruginosa]
ATGAAGTACAGCGAGTTTCGGCGCTGGTTGAAGGCTCGGGGAGTCATTTTCGAGCCTGCCAAGGGAAGCCACTTCAAGGT
CTACTACGGCGACAACCAGACGATCTTCCCTGACCATGGAGCCAAGGAAATAGGCGATGGGTTGAGGAAGAAGATAATCA
AAGACCTGGGCCTCAAGGATTGA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 14970.22 Da        Isoelectric Point: 4.9047

>AT38541 WP_019725767.1 NZ_AP024513:626497-626919 [Pseudomonas aeruginosa]
MFDYPVTVHEEAGSVWVSCDDVPEMASAGDTVDEALLDAVEGLESALSLYVDRRQSIPLPSKGKAGQSIVRLPALTSAKI
ALWNTMLAQNVGKAELARRLGVNRVQVDRLVDLLHGSKIEAVEHALAILGQRLAVTVIAA

Download         Length: 423 bp

>AT38541 NZ_AP024513:626497-626919 [Pseudomonas aeruginosa]
ATGTTTGACTATCCCGTAACGGTTCACGAGGAAGCCGGCAGCGTGTGGGTCAGCTGCGACGATGTACCCGAAATGGCGAG
CGCCGGAGATACCGTTGATGAAGCGCTGCTGGACGCTGTGGAAGGCCTAGAGTCGGCCCTGTCGCTCTATGTGGACCGGA
GGCAGTCGATCCCTCTGCCGTCGAAAGGCAAAGCGGGTCAGTCGATCGTTCGATTGCCCGCGCTCACTTCGGCCAAGATT
GCGCTGTGGAACACCATGCTGGCTCAGAACGTAGGGAAGGCGGAACTGGCTCGCCGGCTGGGAGTGAATCGCGTCCAGGT
AGACCGCCTGGTGGATCTGCTCCACGGGTCGAAGATCGAAGCGGTGGAACATGCTCTGGCGATCTTGGGCCAACGGTTGG
CTGTGACTGTCATTGCGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References