Detailed information of TA system TA038539

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2867203..2867717
• Replicon: chromosome
• Accession: NZ_AP024511
• Organism: Staphylococcus aureus isolate 2007-13

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: A0A0H3K0C1
• Locus tag: KJS82_RS14210
• Protein ID: WP_001078344.1
• Coordinates: 2867391..2867717 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: KJS82_RS14205
• Protein ID: WP_223200634.1
• Coordinates: 2867203..2867388 (+)
• Length: 62 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KJS82_RS14170 (2862425)	2862425..2862709	+	285	WP_000917289.1	co-chaperone GroES	-
KJS82_RS14175 (2862785)	2862785..2864401	+	1617	WP_000240642.1	chaperonin GroEL	-
KJS82_RS14180 (2864470)	2864470..2865642	-	1173	WP_000179343.1	tyrosine-type recombinase/integrase	-
KJS82_RS14185 (2865656)	2865656..2866330	-	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
KJS82_RS14190 (2866503)	2866503..2866721	+	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
KJS82_RS14195 (2866726)	2866726..2867043	+	318	WP_000481967.1	helix-turn-helix domain-containing protein	-
KJS82_RS14200 (2867040)	2867040..2867186	+	147	WP_000784885.1	hypothetical protein	-
KJS82_RS14205 (2867203)	2867203..2867388	+	186	WP_223200634.1	pathogenicity island protein	Antitoxin
KJS82_RS14210 (2867391)	2867391..2867717	+	327	WP_001078344.1	DUF1474 family protein	Toxin
KJS82_RS14215 (2867782)	2867782..2868651	+	870	WP_001002689.1	primase alpha helix C-terminal domain-containing protein	-
KJS82_RS14220 (2868665)	2868665..2870374	+	1710	WP_213607923.1	DUF927 domain-containing protein	-
KJS82_RS14225 (2870684)	2870684..2871064	+	381	WP_000356942.1	hypothetical protein	-
KJS82_RS14230 (2871061)	2871061..2871702	+	642	WP_001047698.1	hypothetical protein	-
KJS82_RS14235 (2872152)	2872152..2872493	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / tsst-1 / sec / sell / hlb	2862425..2906384	43959

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12968.26 Da
• Isoelectric Point: 4.3050

>T38539 WP_001078344.1 NZ_AP024511:2867391-2867717 [Staphylococcus aureus]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Nucleotide

• Length: 327 bp

>T38539 NZ_AP024511:2867391-2867717 [Staphylococcus aureus]
ATGAATCGGGAAATTAAAGATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAGTAATGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin

Protein

• Length: 62 a.a.
• Molecular weight: 7233.15 Da
• Isoelectric Point: 4.4184

>AT38539 WP_223200634.1 NZ_AP024511:2867203-2867388 [Staphylococcus aureus]
IEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 186 bp

>AT38539 NZ_AP024511:2867203-2867388 [Staphylococcus aureus]
ATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCGTGAATAATTTGGAAAGTTATGAACACACAGAATATGTTAATGG
TATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAATGGTGCGCACAAGAATTAAAGAATA
ATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: A0A0H3K0C1