Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2794055..2794569 Replicon chromosome
Accession NZ_AP024511
Organism Staphylococcus aureus isolate 2007-13

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KJS82_RS13845 Protein ID WP_000581792.1
Coordinates 2794360..2794569 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KJS82_RS13840 Protein ID WP_000138932.1
Coordinates 2794055..2794348 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJS82_RS13820 (2789518) 2789518..2790159 + 642 WP_000483153.1 thiamine phosphate synthase -
KJS82_RS13825 (2790245) 2790245..2791117 + 873 WP_000725802.1 membrane protein insertase YidC -
KJS82_RS13830 (2791730) 2791730..2792377 - 648 WP_001187630.1 HD domain-containing protein -
KJS82_RS13835 (2792405) 2792405..2793889 - 1485 WP_000571549.1 cardiolipin synthase -
KJS82_RS13840 (2794055) 2794055..2794348 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KJS82_RS13845 (2794360) 2794360..2794569 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KJS82_RS13850 (2794697) 2794697..2794834 + 138 WP_000828354.1 Lmo0850 family protein -
KJS82_RS13855 (2795098) 2795098..2796300 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KJS82_RS13860 (2796618) 2796618..2797688 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
KJS82_RS13865 (2797703) 2797703..2799061 + 1359 WP_000611464.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T38537 WP_000581792.1 NZ_AP024511:2794360-2794569 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T38537 NZ_AP024511:2794360-2794569 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT38537 WP_000138932.1 NZ_AP024511:2794055-2794348 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT38537 NZ_AP024511:2794055-2794348 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References