Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1258444..1258921 Replicon chromosome
Accession NZ_AP024511
Organism Staphylococcus aureus isolate 2007-13

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KJS82_RS06440 Protein ID WP_000052076.1
Coordinates 1258733..1258921 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KJS82_RS06435 Protein ID WP_001059690.1
Coordinates 1258444..1258704 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJS82_RS06400 (1253837) 1253837..1254553 - 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -
KJS82_RS06405 (1254701) 1254701..1255123 + 423 WP_000974460.1 organic hydroperoxide resistance protein -
KJS82_RS06410 (1255522) 1255522..1256016 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
KJS82_RS06415 (1256171) 1256171..1256788 + 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
KJS82_RS06420 (1256861) 1256861..1257442 - 582 WP_001140693.1 histidine phosphatase family protein -
KJS82_RS06425 (1257667) 1257667..1257903 + 237 WP_000349581.1 hypothetical protein -
KJS82_RS06430 (1257900) 1257900..1258103 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KJS82_RS06435 (1258444) 1258444..1258704 + 261 WP_001059690.1 hypothetical protein Antitoxin
KJS82_RS06440 (1258733) 1258733..1258921 + 189 WP_000052076.1 hypothetical protein Toxin
KJS82_RS06445 (1259109) 1259109..1259678 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
KJS82_RS06450 (1259766) 1259766..1260050 + 285 WP_001004399.1 hypothetical protein -
KJS82_RS06455 (1260112) 1260112..1260330 + 219 WP_000005886.1 hypothetical protein -
KJS82_RS06460 (1260822) 1260822..1261022 - 201 WP_001059082.1 cold-shock protein -
KJS82_RS06465 (1261379) 1261379..1262065 - 687 WP_000141557.1 thermonuclease family protein -
KJS82_RS06470 (1262406) 1262406..1262927 - 522 WP_000824482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T38528 WP_000052076.1 NZ_AP024511:1258733-1258921 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T38528 NZ_AP024511:1258733-1258921 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT38528 WP_001059690.1 NZ_AP024511:1258444-1258704 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT38528 NZ_AP024511:1258444-1258704 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References