Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 546353..547141 Replicon chromosome
Accession NZ_AP024511
Organism Staphylococcus aureus isolate 2007-13

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag KJS82_RS03015 Protein ID WP_000525004.1
Coordinates 546353..546814 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag KJS82_RS03020 Protein ID WP_000333630.1
Coordinates 546827..547141 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KJS82_RS02990 (541363) 541363..543390 + 2028 WP_001813515.1 hypothetical protein -
KJS82_RS02995 (543433) 543433..544638 - 1206 WP_000264751.1 site-specific integrase -
KJS82_RS03000 (544764) 544764..545378 + 615 WP_000191459.1 hypothetical protein -
KJS82_RS03005 (545375) 545375..545521 - 147 WP_001013104.1 hypothetical protein -
KJS82_RS03010 (545751) 545751..546335 - 585 WP_000825948.1 hypothetical protein -
KJS82_RS03015 (546353) 546353..546814 - 462 WP_000525004.1 hypothetical protein Toxin
KJS82_RS03020 (546827) 546827..547141 - 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
KJS82_RS03025 (547293) 547293..547529 + 237 WP_001121027.1 helix-turn-helix transcriptional regulator -
KJS82_RS03030 (547543) 547543..548319 + 777 WP_001148544.1 Rha family transcriptional regulator -
KJS82_RS03035 (548348) 548348..548491 + 144 WP_000939498.1 hypothetical protein -
KJS82_RS03040 (548481) 548481..548690 - 210 WP_000642492.1 hypothetical protein -
KJS82_RS03045 (548746) 548746..548991 + 246 WP_001025401.1 DUF2829 domain-containing protein -
KJS82_RS03050 (548960) 548960..549325 - 366 WP_001128433.1 hypothetical protein -
KJS82_RS03055 (549380) 549380..549595 + 216 WP_001097552.1 hypothetical protein -
KJS82_RS03060 (549620) 549620..549883 + 264 WP_001124160.1 helix-turn-helix domain-containing protein -
KJS82_RS03065 (549896) 549896..550057 + 162 WP_001285954.1 DUF1270 domain-containing protein -
KJS82_RS03070 (550136) 550136..550459 + 324 WP_000174998.1 hypothetical protein -
KJS82_RS03075 (550474) 550474..550836 + 363 WP_000985984.1 hypothetical protein -
KJS82_RS03080 (550833) 550833..551999 + 1167 WP_000762547.1 DUF2800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T38523 WP_000525004.1 NZ_AP024511:c546814-546353 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T38523 NZ_AP024511:c546814-546353 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT38523 WP_000333630.1 NZ_AP024511:c547141-546827 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT38523 NZ_AP024511:c547141-546827 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References