Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5410096..5410727 Replicon chromosome
Accession NZ_AP024503
Organism Pseudomonas protegens strain Go58

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PproGo58_RS23860 Protein ID WP_102860369.1
Coordinates 5410096..5410494 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PproGo58_RS23865 Protein ID WP_102860368.1
Coordinates 5410494..5410727 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PproGo58_RS23835 5406499..5406861 + 363 WP_205413487.1 hypothetical protein -
PproGo58_RS23840 5406871..5407440 - 570 WP_115580841.1 hypothetical protein -
PproGo58_RS23845 5407577..5409625 - 2049 WP_207166500.1 c-type cytochrome -
PproGo58_RS23850 5409840..5409956 - 117 Protein_4705 ArsR family transcriptional regulator -
PproGo58_RS23855 5409945..5410073 + 129 Protein_4706 DUF2938 domain-containing protein -
PproGo58_RS23860 5410096..5410494 - 399 WP_102860369.1 tRNA(fMet)-specific endonuclease VapC Toxin
PproGo58_RS23865 5410494..5410727 - 234 WP_102860368.1 antitoxin Antitoxin
PproGo58_RS23870 5410905..5411114 + 210 Protein_4709 hypothetical protein -
PproGo58_RS23875 5411235..5412482 + 1248 WP_207166501.1 aminotransferase class III-fold pyridoxal phosphate-dependent enzyme -
PproGo58_RS23880 5412507..5413091 - 585 WP_102860366.1 hypothetical protein -
PproGo58_RS23885 5413096..5413536 - 441 WP_180988506.1 DUF3592 domain-containing protein -
PproGo58_RS23890 5413660..5414490 - 831 WP_207166502.1 amidohydrolase family protein -
PproGo58_RS23895 5414643..5415269 + 627 WP_207166503.1 SMI1/KNR4 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15077.41 Da        Isoelectric Point: 7.9042

>T38513 WP_102860369.1 NZ_AP024503:c5410494-5410096 [Pseudomonas protegens]
MLKYMLDTNICIFTIKNKPEQVRDAFRRHQGRLCISTITLMELIYGAEKSAIPERNLSRVESFVARLQVLDYDDVAAIHS
GQLHAELARQGKQIGPYDQLIAGHARSLGLTLITNNLREFERVPGLRVEDWV

Download         Length: 399 bp

>T38513 NZ_AP024503:c5410494-5410096 [Pseudomonas protegens]
ATGCTCAAGTACATGCTGGATACCAATATCTGCATCTTTACCATCAAGAACAAACCTGAACAGGTTCGCGACGCGTTCAG
GCGTCATCAGGGGCGTTTGTGCATCAGCACCATCACCTTGATGGAGCTGATTTACGGTGCGGAAAAATCTGCCATCCCCG
AAAGGAATCTCAGCCGCGTCGAGAGTTTTGTGGCGCGGTTGCAGGTGCTTGATTATGACGATGTCGCCGCCATCCACAGC
GGCCAGTTGCATGCTGAGCTGGCCCGACAGGGCAAGCAGATAGGTCCTTACGATCAATTGATAGCTGGCCACGCTCGATC
TTTGGGGTTGACGCTGATTACCAACAACCTTCGGGAATTTGAACGTGTTCCTGGCTTGCGGGTTGAGGATTGGGTCTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8787.73 Da        Isoelectric Point: 4.2342

>AT38513 WP_102860368.1 NZ_AP024503:c5410727-5410494 [Pseudomonas protegens]
METGSVFKSNRSQAIRMPKAVALPDDVTRVDIVAIGRTRIITPAGESWDSWFDEDDRVSADFMNERDQPAEQVREEF

Download         Length: 234 bp

>AT38513 NZ_AP024503:c5410727-5410494 [Pseudomonas protegens]
ATGGAAACCGGCTCTGTGTTCAAAAGTAATCGCAGCCAGGCCATTCGCATGCCTAAAGCTGTGGCGCTGCCGGATGATGT
CACACGGGTAGACATCGTCGCGATTGGTCGCACCCGTATCATTACCCCGGCGGGGGAGTCCTGGGACAGTTGGTTCGACG
AGGACGACCGTGTAAGCGCTGACTTCATGAATGAACGGGACCAGCCAGCCGAGCAAGTGCGTGAGGAGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References