Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4034692..4035347 Replicon chromosome
Accession NZ_AP024503
Organism Pseudomonas protegens strain Go58

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PproGo58_RS17735 Protein ID WP_102864928.1
Coordinates 4034692..4034871 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PproGo58_RS17740 Protein ID WP_102864927.1
Coordinates 4034922..4035347 (+) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PproGo58_RS17705 4029923..4030198 + 276 WP_011061856.1 peptidylprolyl isomerase -
PproGo58_RS17710 4030284..4031201 - 918 WP_102864933.1 sugar kinase -
PproGo58_RS17715 4031319..4032536 - 1218 WP_110653569.1 amino acid deaminase -
PproGo58_RS17720 4032584..4033348 - 765 WP_207166113.1 helix-turn-helix domain-containing protein -
PproGo58_RS17725 4033514..4033903 - 390 WP_102864930.1 RidA family protein -
PproGo58_RS17730 4034336..4034602 + 267 WP_207166114.1 hypothetical protein -
PproGo58_RS17735 4034692..4034871 + 180 WP_102864928.1 type II toxin-antitoxin system HicA family toxin Toxin
PproGo58_RS17740 4034922..4035347 + 426 WP_102864927.1 transcriptional regulator Antitoxin
PproGo58_RS17745 4035419..4035964 - 546 WP_146036435.1 hypothetical protein -
PproGo58_RS17750 4036155..4037588 - 1434 WP_102864925.1 RtcB family protein -
PproGo58_RS17755 4037766..4038548 - 783 WP_146036434.1 hypothetical protein -
PproGo58_RS17760 4038685..4039509 - 825 WP_102864923.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6659.70 Da        Isoelectric Point: 11.1475

>T38511 WP_102864928.1 NZ_AP024503:4034692-4034871 [Pseudomonas protegens]
MKFSEFRRWLKAQGVVFEAGKGSHFKVKAPNGNQTTFADHGSKEMPEPTRKAIIRQLGL

Download         Length: 180 bp

>T38511 NZ_AP024503:4034692-4034871 [Pseudomonas protegens]
ATGAAATTCAGCGAATTCAGACGATGGTTGAAAGCTCAAGGCGTGGTCTTCGAGGCCGGTAAAGGCAGCCACTTCAAAGT
TAAGGCCCCAAACGGCAACCAGACCACCTTCGCGGATCACGGCAGCAAGGAAATGCCCGAACCCACCCGCAAGGCAATCA
TCAGGCAATTGGGGCTCTAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15699.05 Da        Isoelectric Point: 4.9375

>AT38511 WP_102864927.1 NZ_AP024503:4034922-4035347 [Pseudomonas protegens]
MYDYALRFEQDRAPGLAVFCRDLPELNSFGDDPEHAINQAIDALETTLSLYVDQRRAIPPASAPLPGEQVIHLPMVTVAK
IALWNTMMERDMRKADLCRLLGIHQAQGDRLVDFLHSSKMEQLENALAALGKRLAVSVEAA

Download         Length: 426 bp

>AT38511 NZ_AP024503:4034922-4035347 [Pseudomonas protegens]
ATGTACGACTACGCCCTTCGCTTCGAGCAAGACCGTGCACCGGGACTGGCGGTCTTCTGCCGCGATCTGCCCGAACTCAA
TAGCTTTGGCGATGATCCTGAGCACGCCATCAACCAGGCCATCGACGCGCTCGAAACCACTCTGTCCCTTTACGTCGACC
AGCGCCGCGCCATTCCCCCGGCCTCCGCGCCGCTACCAGGGGAACAGGTCATTCATTTGCCAATGGTGACCGTGGCCAAG
ATAGCGCTGTGGAACACGATGATGGAGCGGGACATGCGCAAGGCCGATCTATGCCGACTGCTCGGAATCCACCAGGCCCA
GGGAGATCGCCTAGTGGACTTTCTACACAGCTCCAAAATGGAACAGCTGGAAAATGCCCTGGCAGCCCTAGGTAAACGTC
TTGCAGTATCAGTGGAGGCGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References