Detailed information of TA system TA038509

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2766708..2767338
• Replicon: chromosome
• Accession: NZ_AP024503
• Organism: Pseudomonas protegens strain Go58

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: PproGo58_RS12590
• Protein ID: WP_108543126.1
• Coordinates: 2767159..2767338 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: PproGo58_RS12585
• Protein ID: WP_102864418.1
• Coordinates: 2766708..2767115 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PproGo58_RS12570	2763448..2764503	+	1056	WP_207167628.1	ABC transporter substrate-binding protein	-
PproGo58_RS12575	2764515..2764964	+	450	WP_207168039.1	peptide-methionine (S)-S-oxide reductase MsrA	-
PproGo58_RS12580	2765148..2765420	-	273	WP_207167630.1	hypothetical protein	-
PproGo58_RS12585	2766708..2767115	-	408	WP_102864418.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PproGo58_RS12590	2767159..2767338	-	180	WP_108543126.1	type II toxin-antitoxin system HicA family toxin	Toxin
PproGo58_RS12595	2767467..2768888	-	1422	WP_207167632.1	efflux transporter outer membrane subunit	-
PproGo58_RS12600	2768872..2770038	-	1167	WP_207167634.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6685.92 Da
• Isoelectric Point: 11.1799

>T38509 WP_108543126.1 NZ_AP024503:c2767338-2767159 [Pseudomonas protegens]
VNIRQLIAQIEADGWYLVRVKGSHHHFKHPTKPGLVTIPHPKKDLLAKTVSSILKQARL

Nucleotide

• Length: 180 bp

>T38509 NZ_AP024503:c2767338-2767159 [Pseudomonas protegens]
GTGAACATCCGGCAACTCATCGCCCAGATCGAAGCAGATGGTTGGTATCTGGTCAGGGTCAAGGGCAGTCACCACCACTT
CAAACACCCAACCAAGCCAGGCCTGGTCACCATTCCCCATCCCAAAAAAGATCTACTGGCCAAAACGGTAAGCAGCATAT
TGAAACAAGCCCGGCTCTAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14752.81 Da
• Isoelectric Point: 4.5801

>AT38509 WP_102864418.1 NZ_AP024503:c2767115-2766708 [Pseudomonas protegens]
MLYPIAILPGDDQHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHLELLAEEGAAIPTARTVTLHAANPQYQGCTWAV
IDIDITRYMGKAEKLNITLPGYLLNRIDEYVKHHPEQKSRSGFLAQAALRVLQGV

Nucleotide

• Length: 408 bp

>AT38509 NZ_AP024503:c2767115-2766708 [Pseudomonas protegens]
ATGCTCTATCCCATTGCCATTCTCCCCGGTGACGACCAACACGCCTGGGGTGTGGAAGTACCCGATATTCCTGGCTGCTT
CTCCGCCGGCGACGACCTCGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAAGGCCACCTGGAATTACTGGCCGAAG
AAGGAGCAGCCATTCCCACAGCACGCACAGTGACCCTCCACGCCGCCAATCCCCAGTATCAAGGCTGCACTTGGGCCGTG
ATTGATATCGACATCACTCGCTACATGGGCAAGGCGGAAAAACTCAACATCACGCTGCCGGGCTATTTGCTGAATCGAAT
TGATGAATATGTGAAACATCATCCGGAACAGAAAAGCCGATCGGGCTTTTTGGCTCAGGCCGCGTTGAGGGTCTTGCAGG
GCGTTTGA