Detailed information of TA system TA038496

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-RHH
• Location: 4636741..4637357
• Replicon: chromosome
• Accession: NZ_AP024498
• Organism: Enterobacter asburiae strain En30

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: R2TS_RS22310
• Protein ID: WP_080298642.1
• Coordinates: 4636741..4637112 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A808IJD0
• Locus tag: R2TS_RS22315
• Protein ID: WP_023309753.1
• Coordinates: 4637115..4637357 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
R2TS_RS22295	4634241..4635143	+	903	WP_008501831.1	formate dehydrogenase subunit beta	-
R2TS_RS22300	4635140..4635775	+	636	WP_010436852.1	formate dehydrogenase cytochrome b556 subunit	-
R2TS_RS22305	4635772..4636701	+	930	WP_023309751.1	formate dehydrogenase accessory protein FdhE	-
R2TS_RS22310	4636741..4637112	-	372	WP_080298642.1	type II toxin-antitoxin system VapC family toxin	Toxin
R2TS_RS22315	4637115..4637357	-	243	WP_023309753.1	ribbon-helix-helix protein, CopG family	Antitoxin
R2TS_RS22320	4637557..4638477	+	921	WP_182072195.1	alpha/beta hydrolase	-
R2TS_RS22325	4638486..4639427	-	942	WP_039264191.1	fatty acid biosynthesis protein FabY	-
R2TS_RS22330	4639472..4639909	-	438	WP_008501836.1	D-tyrosyl-tRNA(Tyr) deacylase	-
R2TS_RS22335	4639906..4640787	-	882	WP_033146965.1	virulence factor BrkB family protein	-
R2TS_RS22340	4640781..4641380	-	600	WP_039264189.1	glucose-1-phosphatase	-
R2TS_RS22345	4641469..4641939	-	471	WP_033146967.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-109)

Antitoxin

• Ribbon-helix-helix protein, CopG (12-49)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13688.85 Da
• Isoelectric Point: 6.9789

>T38496 WP_080298642.1 NZ_AP024498:c4637112-4636741 [Enterobacter asburiae]
MEHMAVFDTNILIDLFNNRVEAADAIDRTASHRAISLITWMEVMVGARKHGHEAKTATVMGVFEIIDITRDIAERSVILR
EKHGMKLPDAIILATAQSRNCPLISRNTKDFSGITGVVSPYQL

Nucleotide

• Length: 372 bp

>T38496 NZ_AP024498:c4637112-4636741 [Enterobacter asburiae]
ATGGAGCACATGGCAGTGTTCGATACCAATATACTCATCGATCTTTTTAATAATCGCGTTGAGGCTGCGGATGCAATTGA
TCGCACAGCTTCTCATCGAGCCATTAGTCTGATCACATGGATGGAAGTCATGGTGGGGGCCCGCAAACATGGTCACGAAG
CGAAAACTGCGACAGTGATGGGCGTATTTGAGATTATTGATATCACCCGAGATATCGCTGAAAGAAGTGTAATTCTGCGC
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCTCAGAGCAGAAATTGTCCGTTGATTTCTCGAAA
CACGAAAGACTTTTCGGGCATTACTGGAGTCGTTTCACCTTACCAACTATAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9411.53 Da
• Isoelectric Point: 4.2803

>AT38496 WP_023309753.1 NZ_AP024498:c4637357-4637115 [Enterobacter asburiae]
ISLSADLDMGRILIDLSDDVIQRLDNLKQLRNRPRAELLREAIEQYLDQQSSSVIRDALGLWGNQQEDGLEYERKLREEW

Nucleotide

• Length: 243 bp

>AT38496 NZ_AP024498:c4637357-4637115 [Enterobacter asburiae]
ATAAGTCTTTCCGCGGATCTTGATATGGGCAGAATTCTGATCGATTTGTCTGATGACGTAATTCAACGACTGGATAATCT
GAAGCAGCTGCGTAACCGTCCTCGTGCCGAATTGCTTCGGGAAGCCATTGAGCAATATCTCGACCAGCAGAGTTCATCGG
TTATCCGCGATGCGCTTGGCTTGTGGGGAAACCAGCAGGAAGATGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A808IJD0