Detailed information of TA system TA038495

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3886978..3887635
• Replicon: chromosome
• Accession: NZ_AP024498
• Organism: Enterobacter asburiae strain En30

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: R2TS_RS18620
• Protein ID: WP_182071664.1
• Coordinates: 3886978..3887388 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V3PWU7
• Locus tag: R2TS_RS18625
• Protein ID: WP_010435322.1
• Coordinates: 3887369..3887635 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
R2TS_RS18600	3882971..3884704	-	1734	WP_064673271.1	single-stranded-DNA-specific exonuclease RecJ	-
R2TS_RS18605	3884710..3885423	-	714	WP_047060452.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
R2TS_RS18610	3885452..3886348	-	897	WP_023309098.1	site-specific tyrosine recombinase XerD	-
R2TS_RS18615	3886450..3886971	+	522	WP_039262979.1	flavodoxin FldB	-
R2TS_RS18620	3886978..3887388	-	411	WP_182071664.1	protein YgfX	Toxin
R2TS_RS18625	3887369..3887635	-	267	WP_010435322.1	FAD assembly factor SdhE	Antitoxin
R2TS_RS18630	3887930..3888910	+	981	WP_029739202.1	tRNA-modifying protein YgfZ	-
R2TS_RS18635	3888985..3889644	-	660	WP_033146591.1	hemolysin III family protein	-
R2TS_RS18640	3889810..3890121	-	312	WP_048980550.1	N(4)-acetylcytidine aminohydrolase	-
R2TS_RS18645	3890173..3890904	+	732	WP_032660101.1	MurR/RpiR family transcriptional regulator	-
R2TS_RS18650	3891021..3892454	+	1434	WP_096151314.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16111.11 Da
• Isoelectric Point: 10.9468

>T38495 WP_182071664.1 NZ_AP024498:c3887388-3886978 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLIAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Nucleotide

• Length: 411 bp

>T38495 NZ_AP024498:c3887388-3886978 [Enterobacter asburiae]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGATTGCGGC
CTTTGTTTTGCTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGTTACTGTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATTAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTGTTGCAACAGACGA
CGCAGGGGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10555.02 Da
• Isoelectric Point: 5.1340

>AT38495 WP_010435322.1 NZ_AP024498:c3887635-3887369 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT38495 NZ_AP024498:c3887635-3887369 [Enterobacter asburiae]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: V3PWU7