Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2933782..2934372 Replicon chromosome
Accession NZ_AP024498
Organism Enterobacter asburiae strain En30

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag R2TS_RS14110 Protein ID WP_058841450.1
Coordinates 2933782..2934114 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag R2TS_RS14115 Protein ID WP_058841451.1
Coordinates 2934115..2934372 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
R2TS_RS14095 2929946..2931271 + 1326 WP_182072112.1 SidA/IucD/PvdA family monooxygenase -
R2TS_RS14100 2931298..2933487 + 2190 WP_047061141.1 TonB-dependent siderophore receptor -
R2TS_RS14110 2933782..2934114 - 333 WP_058841450.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
R2TS_RS14115 2934115..2934372 - 258 WP_058841451.1 hypothetical protein Antitoxin
R2TS_RS14120 2934664..2935053 - 390 WP_096150847.1 RidA family protein -
R2TS_RS14125 2935195..2936115 + 921 WP_048980124.1 LysR family transcriptional regulator -
R2TS_RS14130 2936191..2936493 - 303 WP_029741460.1 XRE family transcriptional regulator -
R2TS_RS14135 2936498..2936851 - 354 WP_048980127.1 type II toxin-antitoxin system RelE/ParE family toxin -
R2TS_RS14140 2937029..2937922 - 894 WP_048980130.1 LysR family transcriptional regulator -
R2TS_RS14145 2938093..2938701 + 609 WP_080973612.1 glutathione S-transferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11757.57 Da        Isoelectric Point: 9.4051

>T38492 WP_058841450.1 NZ_AP024498:c2934114-2933782 [Enterobacter asburiae]
MDRGEIWLVSLDPIAGHEQSGKRPVLVVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEGAGTTTTGVIRCDQPRTI
DMAARNGMRLERIPDAVVNEVLARLDAILS

Download         Length: 333 bp

>T38492 NZ_AP024498:c2934114-2933782 [Enterobacter asburiae]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTTCTTGT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGTTACCGGTAGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGTTTCACCGTTTCACTGGAAGGGGCGGGGACAACAACAACGGGCGTTATTCGCTGTGACCAGCCCAGAACCATT
GATATGGCTGCCCGGAACGGCATGCGGCTGGAACGTATACCTGACGCCGTTGTAAATGAAGTGCTTGCCAGACTGGATGC
GATTCTGAGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9490.96 Da        Isoelectric Point: 4.3351

>AT38492 WP_058841451.1 NZ_AP024498:c2934372-2934115 [Enterobacter asburiae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPYAEMSEEEREWIDAPAV
GREIL

Download         Length: 258 bp

>AT38492 NZ_AP024498:c2934372-2934115 [Enterobacter asburiae]
ATGTATACAACTCGTCTGAAAAAGGTCGGCGGATCCATCATGCTGGCAGTTCCTCCCGCCGTGCTGAAAACGCTGGAGCT
GTCGACGGACAGCGAAGTCGGCATGACCATTAATAATGGCTGCCTGATTATTGAACCCCAGAAGCGGCCTCACTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGTACGCTGAAATGAGCGAAGAGGAGCGGGAATGGATCGATGCGCCTGCGGTG
GGCAGGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References