Detailed information of TA system TA038480

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 261298..261890
• Replicon: chromosome
• Accession: NZ_AP024498
• Organism: Enterobacter asburiae strain En30

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: R2TS_RS01185
• Protein ID: WP_182072249.1
• Coordinates: 261588..261890 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: R2TS_RS01180
• Protein ID: WP_096151293.1
• Coordinates: 261298..261585 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
R2TS_RS01175	259670..261301	+	1632	WP_033144374.1	Na/Pi cotransporter family protein	-
R2TS_RS01180	261298..261585	-	288	WP_096151293.1	putative addiction module antidote protein	Antitoxin
R2TS_RS01185	261588..261890	-	303	WP_182072249.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
R2TS_RS01190	262088..262960	+	873	WP_033144377.1	23S rRNA pseudouridine(2604) synthase RluF	-
R2TS_RS01195	262961..263233	-	273	WP_023309994.1	DUF3811 domain-containing protein	-
R2TS_RS01200	263284..264228	-	945	WP_096151294.1	ketopantoate/pantoate/pantothenate transporter PanS	-
R2TS_RS01205	264322..265671	-	1350	WP_023309996.1	lysine-sensitive aspartokinase 3	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-92)

Antitoxin

• Uncharacterized protein HI1420 (3-90)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11284.02 Da
• Isoelectric Point: 9.9325

>T38480 WP_182072249.1 NZ_AP024498:c261890-261588 [Enterobacter asburiae]
MKEIVQTESFQRWEQNLKDRRAKTIIASRLFRLANGLAGDIKPVGEGISELRIHYGPGYRLYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNPNGRSE

Nucleotide

• Length: 303 bp

>T38480 NZ_AP024498:c261890-261588 [Enterobacter asburiae]
ATGAAGGAGATCGTTCAGACAGAATCCTTCCAACGCTGGGAGCAAAACTTAAAAGATCGGCGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGTTTAGCGGGCGACATTAAACCCGTGGGCGAAGGTATAAGTGAGCTGAGGATCC
ACTATGGTCCGGGCTATAGACTCTATTTTAAAGACCAGGGCAATTGCATCATCGTGCTGTTGTGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTTATGGCAAAAATGCTGAGCAATCCCAATGGCAGGAGTGAATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10183.66 Da
• Isoelectric Point: 5.6557

>AT38480 WP_096151293.1 NZ_AP024498:c261585-261298 [Enterobacter asburiae]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKHAED

Nucleotide

• Length: 288 bp

>AT38480 NZ_AP024498:c261585-261298 [Enterobacter asburiae]
ATGCATAAATTAACACCCTACGATCCAGCCAATGCGCTGGTGGATGACGAGGAAATCGCCGTGTTTATGGCTGATGCCTT
AGAAACGGGCGACTCAGCGTATATTGCTAAAGCTCTGGGCGTCATCGCGCGAGCGAAAGGAATGTCGACCATTTCACAGC
AAACTGGCCTATCACGAGAGCAACTGTATCGATCGTTCAGTGATAAAGGAAACCCAACGCTTAAAACCACTCTGGCGGTC
ATGAAAGCATTGGGTCTTGGGCTAACAATCAAACACGCCGAAGATTAA