Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 52188..52850 Replicon chromosome
Accession NZ_AP024498
Organism Enterobacter asburiae strain En30

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag R2TS_RS00255 Protein ID WP_176686521.1
Coordinates 52452..52850 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag R2TS_RS00250 Protein ID WP_182072104.1
Coordinates 52188..52448 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
R2TS_RS00235 49613..50734 - 1122 WP_182072100.1 efflux RND transporter periplasmic adaptor subunit -
R2TS_RS00240 50883..51452 - 570 WP_033144322.1 TetR family transcriptional regulator -
R2TS_RS00245 51639..52058 + 420 WP_182072102.1 GNAT family N-acetyltransferase -
R2TS_RS00250 52188..52448 + 261 WP_182072104.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
R2TS_RS00255 52452..52850 + 399 WP_176686521.1 type II toxin-antitoxin system VapC family toxin Toxin
R2TS_RS00260 52991..53791 + 801 WP_182072106.1 lipoprotein NlpA -
R2TS_RS00265 53914..54693 + 780 WP_182072108.1 MBL fold metallo-hydrolase -
R2TS_RS00270 54720..55673 + 954 WP_182072110.1 helix-turn-helix domain-containing protein -
R2TS_RS00275 55905..57554 + 1650 WP_207168178.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14961.16 Da        Isoelectric Point: 6.0840

>T38479 WP_176686521.1 NZ_AP024498:52452-52850 [Enterobacter asburiae]
MLHMLDTNMVSHLVRQHPGVLEQYSRTPTEKMCISSVTEAELLYGIAKKQNDTLQKTILEFLKTITICDWDSDAAATYGE
LRAAMEKRGKVMGDLDQLIAAHAISRRTTIVTNDRAFRMVQELTVEDWTTTS

Download         Length: 399 bp

>T38479 NZ_AP024498:52452-52850 [Enterobacter asburiae]
ATGCTGCATATGTTGGATACAAACATGGTAAGCCATCTCGTGAGACAACATCCTGGGGTGTTGGAACAATATTCTCGCAC
CCCAACTGAAAAAATGTGTATTTCAAGCGTAACGGAGGCTGAATTGCTTTATGGGATAGCCAAAAAGCAAAACGACACAT
TACAAAAAACCATACTGGAATTTCTTAAAACCATTACGATTTGCGACTGGGACAGTGACGCCGCCGCAACGTACGGCGAA
CTCCGCGCAGCAATGGAGAAGAGAGGAAAAGTGATGGGCGATCTCGATCAACTGATCGCTGCGCATGCTATCAGTCGGAG
AACAACGATTGTGACTAACGATCGTGCATTCAGAATGGTGCAGGAGCTTACCGTAGAGGACTGGACGACAACGTCGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10176.44 Da        Isoelectric Point: 8.5750

>AT38479 WP_182072104.1 NZ_AP024498:52188-52448 [Enterobacter asburiae]
MERTAKLFKKGRNQAVMIPAEFAFDTESVYIRRDEEGNVVLTARSEKERHRDNFLRLLKQTHVPDSFLSKEERNQSYTTR
DPFEGL

Download         Length: 261 bp

>AT38479 NZ_AP024498:52188-52448 [Enterobacter asburiae]
ATGGAACGCACAGCAAAACTCTTTAAAAAGGGGCGGAATCAGGCCGTAATGATACCTGCTGAATTCGCGTTTGATACGGA
GAGCGTCTACATCCGGCGGGATGAGGAGGGGAATGTCGTTTTGACTGCGAGATCGGAGAAAGAGCGGCATCGAGATAACT
TTTTACGTTTATTGAAGCAGACCCATGTTCCTGATTCATTCCTCAGCAAAGAGGAACGTAATCAGAGCTATACAACAAGA
GATCCCTTTGAAGGACTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References