Detailed information of TA system TA038478

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3870975..3871506
• Replicon: chromosome
• Accession: NZ_AP024488
• Organism: Desulfoluna limicola strain ASN36

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L6434_RS14815
• Protein ID: WP_236888858.1
• Coordinates: 3870975..3871265 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: L6434_RS14820
• Protein ID: WP_236888859.1
• Coordinates: 3871255..3871506 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L6434_RS14810 (DSLASN_30630)	3869203..3870369	+	1167	WP_236888857.1	DUF2220 family protein	-
L6434_RS14815 (DSLASN_30640)	3870975..3871265	-	291	WP_236888858.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L6434_RS14820 (DSLASN_30650)	3871255..3871506	-	252	WP_236888859.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
L6434_RS14825 (DSLASN_30670)	3872294..3875506	+	3213	WP_236888860.1	PilZ domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11257.27 Da
• Isoelectric Point: 10.3910

>T38478 WP_236888858.1 NZ_AP024488:c3871265-3870975 [Desulfoluna limicola]
MPYKLKFLPTALKEWKKLDNTISTQLKKKLEEVLQNPRIQANQLRNFENHYKIKLRASGYRLVYEVIDDEIVVLVIAIGK
REGNKIYEVAKLRSGV

Nucleotide

• Length: 291 bp

>T38478 NZ_AP024488:c3871265-3870975 [Desulfoluna limicola]
ATGCCCTATAAACTTAAGTTTCTGCCGACAGCCCTCAAAGAATGGAAAAAACTCGATAACACCATCAGTACCCAGCTCAA
AAAAAAACTTGAAGAGGTTCTTCAAAACCCAAGAATCCAAGCCAACCAACTCAGAAACTTTGAGAACCACTACAAAATCA
AACTCAGAGCCTCTGGCTATCGTTTGGTTTACGAGGTAATTGACGACGAAATTGTCGTGTTGGTAATCGCCATCGGTAAA
AGAGAAGGCAATAAAATCTATGAGGTGGCGAAGCTACGGTCTGGCGTGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9070.34 Da
• Isoelectric Point: 4.5799

>AT38478 WP_236888859.1 NZ_AP024488:c3871506-3871255 [Desulfoluna limicola]
MEPIYAKFSASISELKKNPSSLIQEADGCAITILNHNKPTAYLVPAATYEALLDRIEDHELGKIVLERQSEKGSALEVSL
DAL

Nucleotide

• Length: 252 bp

>AT38478 NZ_AP024488:c3871506-3871255 [Desulfoluna limicola]
ATGGAACCCATATACGCAAAATTCTCTGCAAGCATCTCGGAGCTCAAAAAAAATCCGAGTTCCCTCATCCAAGAGGCCGA
TGGGTGTGCAATCACCATCTTAAACCACAATAAACCCACGGCTTATCTGGTTCCAGCCGCTACATACGAGGCACTTCTCG
ATAGAATAGAAGACCACGAGCTGGGTAAAATTGTTCTTGAGCGGCAATCAGAGAAAGGTAGTGCCCTTGAGGTGTCATTA
GATGCCCTATAA