Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 1599122..1599685 Replicon chromosome
Accession NZ_AP024487
Organism MAG: Metallosphaera javensis (ex Sakai et al. 2022) isolate AS-7

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QVC96_RS09240 Protein ID WP_287689023.1
Coordinates 1599419..1599685 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QVC96_RS09235 Protein ID WP_287690469.1
Coordinates 1599122..1599310 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QVC96_RS09215 (MjAS7_1947) 1594234..1594617 - 384 WP_287689022.1 HEPN domain-containing protein -
QVC96_RS09220 (MjAS7_1948) 1595048..1595521 - 474 WP_238026407.1 hypothetical protein -
QVC96_RS09225 (MjAS7_1949) 1595511..1596815 - 1305 WP_238026405.1 AAA family ATPase -
QVC96_RS09230 (MjAS7_1951) 1597488..1598553 - 1066 Protein_1808 transposase -
QVC96_RS09235 (MjAS7_1954) 1599122..1599310 + 189 WP_287690469.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QVC96_RS09240 (MjAS7_1956) 1599419..1599685 + 267 WP_287689023.1 hypothetical protein Toxin
QVC96_RS09245 (MjAS7_1957) 1599863..1600108 + 246 WP_287689024.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
QVC96_RS09250 (MjAS7_1958) 1600086..1600475 + 390 WP_287689025.1 type II toxin-antitoxin system VapC family toxin -
QVC96_RS09255 1601828..1601953 + 126 WP_287689026.1 hypothetical protein -
QVC96_RS09260 (MjAS7_1960) 1602302..1603810 - 1509 WP_287689027.1 ankyrin repeat domain-containing protein -
QVC96_RS09265 (MjAS7_1961) 1603895..1604056 + 162 WP_287689028.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

SpoVT-AbrB domain

(1-35)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10260.85 Da        Isoelectric Point: 9.5626

>T38475 WP_287689023.1 NZ_AP024487:1599419-1599685 [Metallosphaera javensis (ex Sakai et al. 2022)]
MVWFFRRNGLDSRIGDVISYLNHEKAELSEDNSRVLRKGLEIISSEKLSLSHYNDVIILSHSIINELPLVSFDRNLMKLA
RKYNVKTL

Download         Length: 267 bp

>T38475 NZ_AP024487:1599419-1599685 [Metallosphaera javensis (ex Sakai et al. 2022)]
ATGGTCTGGTTTTTCAGGAGGAATGGGCTGGACAGCAGGATAGGTGACGTGATCTCCTACCTGAATCACGAGAAAGCGGA
GCTCTCGGAGGACAACTCCAGGGTGTTGAGGAAGGGACTGGAGATCATCTCGTCGGAGAAGCTATCCCTATCCCACTACA
ATGACGTGATCATTCTGTCCCATTCCATTATCAATGAACTGCCACTGGTCAGCTTTGACAGGAATTTGATGAAACTGGCC
AGAAAGTACAACGTGAAAACTCTCTGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 7157.14 Da        Isoelectric Point: 5.1617

>AT38475 WP_287690469.1 NZ_AP024487:1599122-1599310 [Metallosphaera javensis (ex Sakai et al. 2022)]
IPASIREKLDIREGDIVEITLNNDEIVIRKARSRRPRIKLNRKLTVDEVERDIEEGMNEGSG

Download         Length: 189 bp

>AT38475 NZ_AP024487:1599122-1599310 [Metallosphaera javensis (ex Sakai et al. 2022)]
ATTCCTGCATCCATAAGGGAGAAACTGGACATAAGGGAGGGCGACATCGTGGAGATCACCCTCAACAACGACGAGATCGT
AATAAGGAAGGCCAGGAGCAGGAGGCCCAGGATAAAACTGAACAGGAAGCTCACCGTGGATGAGGTAGAGAGGGATATAG
AGGAGGGAATGAATGAGGGCAGTGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References