Detailed information of TA system TA038471

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 645268..645889
• Replicon: chromosome
• Accession: NZ_AP024480
• Organism: Caldicellulosiruptor sp. YA01

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: CaldiYA01_RS02820
• Protein ID: WP_207181139.1
• Coordinates: 645268..645450 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CaldiYA01_RS02825
• Protein ID: WP_207181141.1
• Coordinates: 645473..645889 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CaldiYA01_RS02800	640587..641981	+	1395	WP_207181134.1	alpha-glucosidase/alpha-galactosidase	-
CaldiYA01_RS02805	642436..643017	+	582	WP_207181135.1	Uma2 family endonuclease	-
CaldiYA01_RS02810	643242..643659	-	418	Protein_545	type II toxin-antitoxin system HicB family antitoxin	-
CaldiYA01_RS02815	643667..643876	-	210	WP_207181137.1	type II toxin-antitoxin system HicA family toxin	-
CaldiYA01_RS02820	645268..645450	+	183	WP_207181139.1	type II toxin-antitoxin system HicA family toxin	Toxin
CaldiYA01_RS02825	645473..645889	+	417	WP_207181141.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CaldiYA01_RS02830	645904..646836	-	933	WP_207181142.1	sigma-70 family RNA polymerase sigma factor	-
CaldiYA01_RS02835	647209..648310	+	1102	Protein_550	IS481 family transposase	-
CaldiYA01_RS02840	648491..648709	-	219	WP_207181144.1	helix-turn-helix domain-containing protein	-
CaldiYA01_RS02845	648875..649678	+	804	WP_207181146.1	helix-turn-helix domain-containing protein	-
CaldiYA01_RS02850	649659..650240	+	582	WP_207181148.1	Uma2 family endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	643242..649678	6436

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (7-110)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7050.38 Da
• Isoelectric Point: 10.8900

>T38471 WP_207181139.1 NZ_AP024480:645268-645450 [Caldicellulosiruptor sp. YA01]
MKPKELIKILKEDGWYEVRQRGSHKQFRHPVKKGLVTIPFHNKDLDIKTLNSILKQAGLK

Nucleotide

• Length: 183 bp

>T38471 NZ_AP024480:645268-645450 [Caldicellulosiruptor sp. YA01]
TTGAAACCAAAAGAATTGATAAAAATACTTAAAGAAGATGGCTGGTATGAGGTAAGGCAGAGAGGTTCACATAAGCAATT
TAGACATCCTGTTAAAAAAGGATTAGTTACAATTCCATTCCACAATAAAGACCTTGACATAAAAACACTCAATAGCATTC
TCAAGCAGGCAGGATTAAAATAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15565.99 Da
• Isoelectric Point: 5.0668

>AT38471 WP_207181141.1 NZ_AP024480:645473-645889 [Caldicellulosiruptor sp. YA01]
MKDKYIFPAIFEPAEKEGYVVTFPDLPGCITEGKNLEEALYMAKEALELHIYGLEEDGEKIPEPTPPEKLNVSRGAFVVP
IIAYMPPVREEIANKSVNKTVTLPRWLSRAAEEAHINFSQVLQQALKEKLGIKERKNA

Nucleotide

• Length: 417 bp

>AT38471 NZ_AP024480:645473-645889 [Caldicellulosiruptor sp. YA01]
ATGAAAGATAAGTATATTTTCCCAGCTATATTTGAACCGGCAGAAAAAGAAGGCTACGTTGTTACATTTCCAGACTTACC
CGGTTGTATAACAGAAGGTAAAAATCTTGAAGAAGCTTTATACATGGCAAAAGAAGCTTTGGAGCTGCACATCTATGGTT
TAGAAGAAGATGGAGAAAAAATACCTGAACCTACACCACCAGAAAAATTGAATGTTTCAAGAGGTGCTTTTGTAGTTCCA
ATCATTGCATATATGCCACCTGTTAGGGAAGAGATAGCTAACAAAAGCGTAAATAAAACGGTGACACTTCCAAGATGGTT
AAGCAGGGCAGCTGAAGAAGCACATATTAATTTTTCGCAGGTTTTGCAACAAGCTTTGAAAGAAAAACTTGGAATAAAAG
AGCGAAAAAATGCATAA