Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 2282396..2282992 Replicon chromosome
Accession NZ_AP024470
Organism Asaccharobacter celatus DSM 18785

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag ADLECEL_RS09480 Protein ID WP_117284338.1
Coordinates 2282396..2282692 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ADLECEL_RS09485 Protein ID WP_117284337.1
Coordinates 2282705..2282992 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ADLECEL_RS09450 2277785..2278783 + 999 WP_117284343.1 carbon-nitrogen hydrolase family protein -
ADLECEL_RS09455 2278809..2279483 - 675 WP_117284347.1 TetR/AcrR family transcriptional regulator -
ADLECEL_RS09460 2279662..2280624 + 963 WP_117284342.1 hypothetical protein -
ADLECEL_RS09465 2280942..2281421 + 480 WP_117284341.1 peptide-methionine (S)-S-oxide reductase -
ADLECEL_RS09470 2281633..2282040 + 408 WP_117284340.1 hypothetical protein -
ADLECEL_RS09475 2282037..2282303 + 267 WP_117284339.1 hypothetical protein -
ADLECEL_RS09480 2282396..2282692 + 297 WP_117284338.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ADLECEL_RS09485 2282705..2282992 + 288 WP_117284337.1 putative addiction module antidote protein Antitoxin
ADLECEL_RS09490 2283054..2284658 - 1605 WP_117284336.1 glutamine-hydrolyzing GMP synthase -
ADLECEL_RS09495 2284861..2285736 - 876 WP_117284335.1 tyrosine-protein phosphatase -
ADLECEL_RS09500 2285911..2286288 - 378 WP_117284334.1 hypothetical protein -
ADLECEL_RS09505 2286597..2287001 + 405 WP_181965280.1 metalloregulator ArsR/SmtB family transcription factor -
ADLECEL_RS09510 2287072..2287299 + 228 WP_117284333.1 cation transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-89)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11438.38 Da        Isoelectric Point: 10.4470

>T38469 WP_117284338.1 NZ_AP024470:2282396-2282692 [Asaccharobacter celatus DSM 18785]
MITVLQTTEFVKWLKRLKDAEARARILVRIRRLSLTENFGDVKPVGDCVYEMRVEHGPGYRLYYARRDNALVLLLIGGDK
SSQQRDIAKAKKLNLEYR

Download         Length: 297 bp

>T38469 NZ_AP024470:2282396-2282692 [Asaccharobacter celatus DSM 18785]
ATGATAACCGTCCTGCAAACAACCGAGTTCGTGAAATGGCTCAAACGACTCAAAGATGCTGAGGCGCGAGCGCGTATTCT
CGTGAGAATACGGCGCCTTTCACTAACGGAGAATTTTGGAGACGTTAAGCCAGTTGGCGACTGCGTTTATGAGATGCGCG
TCGAGCACGGGCCTGGATATCGTCTCTATTACGCAAGACGGGACAATGCGTTGGTCTTGCTCCTCATCGGTGGAGACAAA
TCATCGCAACAGCGAGACATCGCGAAAGCAAAAAAGCTCAACCTCGAGTACAGGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 9909.17 Da        Isoelectric Point: 4.5105

>AT38469 WP_117284337.1 NZ_AP024470:2282705-2282992 [Asaccharobacter celatus DSM 18785]
MKKATTWDAADYLETEADIAAYLNAAFEDGDTSVIAAALGDVARAKGMTQLSKETGITRDGLYKALSPAGNPSLDTVQKV
VRAFGLKLDVSAVSA

Download         Length: 288 bp

>AT38469 NZ_AP024470:2282705-2282992 [Asaccharobacter celatus DSM 18785]
ATGAAGAAAGCGACAACCTGGGACGCAGCCGACTATCTCGAAACGGAAGCCGACATTGCGGCCTATCTAAATGCCGCCTT
TGAAGACGGCGACACCTCCGTAATCGCCGCCGCCCTTGGCGACGTCGCCCGGGCAAAGGGAATGACGCAGCTCTCAAAGG
AAACCGGCATCACCAGAGACGGTCTTTACAAGGCGTTATCACCGGCAGGGAATCCGTCGCTTGATACCGTACAGAAAGTC
GTGAGGGCCTTTGGACTCAAACTCGACGTTTCGGCAGTCTCGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References