Detailed information of TA system TA038467

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): brnT-shpB/BrnT-BrnA
• Location: 3964899..3965460
• Replicon: chromosome
• Accession: NZ_AP024469
• Organism: Geobacter sp. SVR

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: -
• Locus tag: GSVR_RS18595
• Protein ID: WP_173195892.1
• Coordinates: 3965188..3965460 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: GSVR_RS18590
• Protein ID: WP_173195304.1
• Coordinates: 3964899..3965207 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GSVR_RS18560	3959983..3960342	-	360	WP_173195299.1	hypothetical protein	-
GSVR_RS18565	3960630..3962534	+	1905	WP_173195300.1	transglycosylase domain-containing protein	-
GSVR_RS18570	3962655..3963572	-	918	WP_173195890.1	tRNA-dihydrouridine synthase family protein	-
GSVR_RS18575	3963727..3964062	-	336	WP_173195301.1	toxin	-
GSVR_RS18580	3964104..3964523	-	420	WP_173195302.1	type II toxin-antitoxin system VapC family toxin	-
GSVR_RS18585	3964520..3964801	-	282	WP_173195303.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
GSVR_RS18590	3964899..3965207	-	309	WP_173195304.1	BrnA antitoxin family protein	Antitoxin
GSVR_RS18595	3965188..3965460	-	273	WP_173195892.1	BrnT family toxin	Toxin
GSVR_RS18600	3965553..3966785	-	1233	WP_173195305.1	LL-diaminopimelate aminotransferase	-
GSVR_RS18605	3966832..3968409	-	1578	WP_173195306.1	GGDEF domain-containing protein	-
GSVR_RS18610	3968499..3969269	-	771	WP_173195894.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
GSVR_RS18615	3969321..3969977	-	657	WP_173195307.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	htpB / adeG	3676406..3996929	320523

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (4-81)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (16-94)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10554.68 Da
• Isoelectric Point: 6.0816

>T38467 WP_173195892.1 NZ_AP024469:c3965460-3965188 [Geobacter sp. SVR]
IFEWDENKNRSNRAKHGIDFESAITVFDDPLMQSRVDADGRWQSIGYSEGRILLLFVAHTYHEADEVVVRIISARRASRQ
EREHYEKGSF

Nucleotide

• Length: 273 bp

>T38467 NZ_AP024469:c3965460-3965188 [Geobacter sp. SVR]
ATCTTCGAGTGGGATGAGAACAAGAACCGAAGCAACAGGGCAAAGCACGGAATCGACTTTGAATCGGCAATCACGGTTTT
TGACGATCCGTTGATGCAGAGTCGGGTTGACGCAGATGGTCGATGGCAGTCCATAGGATATTCCGAGGGCCGCATACTGT
TGCTGTTTGTGGCGCACACCTACCATGAAGCAGACGAAGTCGTTGTCAGGATCATATCCGCGAGAAGGGCCAGCAGGCAG
GAAAGGGAGCACTATGAAAAAGGGAGTTTCTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11699.43 Da
• Isoelectric Point: 9.8082

>AT38467 WP_173195304.1 NZ_AP024469:c3965207-3964899 [Geobacter sp. SVR]
MKKGVSENIVRVKGIPKLTEAQCENLKRLAERPDDEIDYSDIPEITDFSGFEVGKFYRPVKESVTVRLDADVVSWLKRGG
KGYQTRLNAILRREMEKNRKAA

Nucleotide

• Length: 309 bp

>AT38467 NZ_AP024469:c3965207-3964899 [Geobacter sp. SVR]
ATGAAAAAGGGAGTTTCTGAAAATATTGTCAGGGTCAAAGGTATCCCAAAATTGACGGAGGCACAGTGTGAAAACCTGAA
GAGGCTCGCCGAGCGCCCGGACGATGAAATTGATTATTCAGACATTCCGGAAATCACCGACTTCAGCGGTTTTGAGGTGG
GCAAGTTCTACCGCCCTGTCAAGGAGTCGGTTACTGTCAGGCTGGATGCGGATGTTGTCAGCTGGCTCAAGCGTGGTGGC
AAGGGGTATCAAACGCGGCTCAACGCCATCCTTCGGCGGGAGATGGAAAAAAATCGCAAGGCGGCGTGA