Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 3964104..3964801 Replicon chromosome
Accession NZ_AP024469
Organism Geobacter sp. SVR

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GSVR_RS18580 Protein ID WP_173195302.1
Coordinates 3964104..3964523 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GSVR_RS18585 Protein ID WP_173195303.1
Coordinates 3964520..3964801 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSVR_RS18560 3959983..3960342 - 360 WP_173195299.1 hypothetical protein -
GSVR_RS18565 3960630..3962534 + 1905 WP_173195300.1 transglycosylase domain-containing protein -
GSVR_RS18570 3962655..3963572 - 918 WP_173195890.1 tRNA-dihydrouridine synthase family protein -
GSVR_RS18575 3963727..3964062 - 336 WP_173195301.1 toxin -
GSVR_RS18580 3964104..3964523 - 420 WP_173195302.1 type II toxin-antitoxin system VapC family toxin Toxin
GSVR_RS18585 3964520..3964801 - 282 WP_173195303.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GSVR_RS18590 3964899..3965207 - 309 WP_173195304.1 BrnA antitoxin family protein -
GSVR_RS18595 3965188..3965460 - 273 WP_173195892.1 BrnT family toxin -
GSVR_RS18600 3965553..3966785 - 1233 WP_173195305.1 LL-diaminopimelate aminotransferase -
GSVR_RS18605 3966832..3968409 - 1578 WP_173195306.1 GGDEF domain-containing protein -
GSVR_RS18610 3968499..3969269 - 771 WP_173195894.1 MetQ/NlpA family ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - htpB / adeG 3676406..3996929 320523


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(13-72)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15554.91 Da        Isoelectric Point: 4.8065

>T38466 WP_173195302.1 NZ_AP024469:c3964523-3964104 [Geobacter sp. SVR]
VKYLLDTCLISELVKKEPNPSVVRWLDEQDEQKLFLSVLNVGELQKGISKLPNGAKKDELQAWVTLDLVERFTGRILDLD
LATALCWGRQQGEAERNGEKLPVMDALIAATAAAHGLVVVTRNVSDMERCGARVWNPWE

Download         Length: 420 bp

>T38466 NZ_AP024469:c3964523-3964104 [Geobacter sp. SVR]
GTGAAATATCTGCTCGATACCTGTCTGATTTCAGAACTGGTAAAAAAAGAGCCAAACCCGTCGGTAGTCAGGTGGCTGGA
CGAGCAGGACGAACAAAAGCTCTTTCTGAGTGTGCTGAACGTGGGGGAGTTGCAGAAGGGTATCAGCAAACTTCCGAACG
GTGCCAAGAAGGATGAGCTGCAGGCATGGGTCACGCTCGACTTGGTGGAGCGTTTTACCGGGCGGATCCTGGACCTCGAC
CTGGCGACAGCGCTATGCTGGGGACGACAGCAGGGGGAAGCGGAACGAAACGGCGAAAAGCTGCCGGTCATGGACGCACT
GATTGCTGCCACGGCTGCAGCCCATGGCCTGGTGGTGGTGACGCGCAATGTCAGTGATATGGAACGTTGCGGTGCACGCG
TGTGGAATCCGTGGGAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10739.99 Da        Isoelectric Point: 7.4041

>AT38466 WP_173195303.1 NZ_AP024469:c3964801-3964520 [Geobacter sp. SVR]
MKTNKKDRSSHDREWQLQEAKNRLSQVVDQALHDGPQTITLRGKPAAVLLSFDEYRNLTRPHTGLSQFFRQSPLHDVELD
VSRSADLSREVEL

Download         Length: 282 bp

>AT38466 NZ_AP024469:c3964801-3964520 [Geobacter sp. SVR]
ATGAAAACAAATAAAAAGGACCGTTCGTCGCATGACCGGGAATGGCAGCTCCAGGAAGCTAAAAATCGTCTGAGCCAGGT
GGTCGATCAGGCGCTACATGATGGTCCGCAGACAATTACCTTGCGGGGCAAACCGGCAGCCGTTCTGCTTTCTTTTGATG
AGTACCGCAACCTGACCAGGCCGCACACGGGCCTGTCGCAATTCTTCCGCCAATCCCCTTTGCACGATGTAGAGCTGGAT
GTCAGCCGCAGCGCCGACCTCTCCAGGGAGGTTGAGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References