Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 6019873..6020512 Replicon chromosome
Accession NZ_AP024464
Organism Pseudomonas amygdali pv. tabaci strain 6605

Toxin (Protein)


Gene name hicA Uniprot ID A0A7Z6Y3C5
Locus tag Pta6605_RS26720 Protein ID WP_005781617.1
Coordinates 6020330..6020512 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0Q0DRU8
Locus tag Pta6605_RS26715 Protein ID WP_016981256.1
Coordinates 6019873..6020298 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Pta6605_RS26700 (Pta6605_53750) 6016339..6017661 + 1323 WP_029240926.1 murein hydrolase activator EnvC -
Pta6605_RS26705 (Pta6605_53760) 6017695..6019032 + 1338 WP_016981257.1 S41 family peptidase -
Pta6605_RS26710 (Pta6605_53770) 6019036..6019818 + 783 WP_005745049.1 divergent polysaccharide deacetylase family protein -
Pta6605_RS26715 (Pta6605_53780) 6019873..6020298 - 426 WP_016981256.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Pta6605_RS26720 (Pta6605_53790) 6020330..6020512 - 183 WP_005781617.1 type II toxin-antitoxin system HicA family toxin Toxin
Pta6605_RS26725 6020834..6021074 + 241 Protein_5284 serine protease -
Pta6605_RS26730 (Pta6605_53800) 6021079..6021834 - 756 WP_004663214.1 ABC transporter substrate-binding protein -
Pta6605_RS26735 (Pta6605_53810) 6022020..6022790 - 771 WP_002551458.1 imidazole glycerol phosphate synthase subunit HisF -
Pta6605_RS26740 (Pta6605_53820) 6022810..6023547 - 738 WP_002551457.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
Pta6605_RS26745 (Pta6605_53830) 6023655..6023915 - 261 WP_016981255.1 DUF2164 domain-containing protein -
Pta6605_RS26750 (Pta6605_53840) 6023920..6024558 - 639 WP_005745046.1 imidazole glycerol phosphate synthase subunit HisH -
Pta6605_RS26755 (Pta6605_53850) 6024558..6025151 - 594 WP_002551454.1 imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-58)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6877.97 Da        Isoelectric Point: 10.6211

>T38462 WP_005781617.1 NZ_AP024464:c6020512-6020330 [Pseudomonas amygdali pv. tabaci]
MKCNEFRRWLQAQGAEFRAAKGSHFKVYLNGKATIFADHGSKEMHEGLRKSIIKQLGLKD

Download         Length: 183 bp

>T38462 NZ_AP024464:c6020512-6020330 [Pseudomonas amygdali pv. tabaci]
ATGAAGTGCAACGAGTTTCGGCGATGGTTGCAGGCTCAAGGCGCTGAGTTCAGGGCTGCCAAGGGTAGTCATTTCAAGGT
TTACCTGAATGGTAAGGCAACCATCTTTGCAGACCATGGAAGCAAAGAAATGCACGAAGGGTTACGCAAGTCGATCATCA
AGCAGCTCGGCCTTAAGGATTGA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15783.24 Da        Isoelectric Point: 5.2548

>AT38462 WP_016981256.1 NZ_AP024464:c6020298-6019873 [Pseudomonas amygdali pv. tabaci]
MYQYPLDLHREPTGVWLSCPDIPEMSASGDTLPEAFSEALDGMESALSLYVDQRRKIPQASVVPGHELLMRLPALTVAKI
MLWNSLLEEGVSRAELARRLGCTRQVVDRLVDFLHASKIEQVERALAELGRRITLSIERAA

Download         Length: 426 bp

>AT38462 NZ_AP024464:c6020298-6019873 [Pseudomonas amygdali pv. tabaci]
ATGTATCAATATCCATTGGATCTACATCGGGAGCCGACAGGCGTTTGGCTGTCGTGTCCAGACATTCCCGAAATGAGCGC
CTCTGGCGACACCCTGCCTGAAGCATTTAGCGAAGCTCTTGACGGCATGGAATCGGCTCTATCGCTCTACGTCGATCAGC
GTCGCAAGATTCCCCAAGCCTCAGTCGTACCCGGCCATGAACTGTTGATGCGTTTGCCTGCGCTGACGGTTGCCAAAATC
ATGCTATGGAACAGCTTGTTGGAAGAGGGCGTTAGCCGTGCTGAGCTGGCGCGTCGCCTCGGTTGCACGCGGCAAGTGGT
GGATCGGCTTGTGGACTTTCTGCATGCCTCGAAAATCGAGCAGGTGGAGCGAGCGCTGGCTGAGCTTGGTCGGCGTATTA
CGTTGAGCATTGAGCGGGCCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z6Y3C5

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q0DRU8

References