Detailed information of TA system TA038462

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 6019873..6020512
• Replicon: chromosome
• Accession: NZ_AP024464
• Organism: Pseudomonas amygdali pv. tabaci strain 6605

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A7Z6Y3C5
• Locus tag: Pta6605_RS26720
• Protein ID: WP_005781617.1
• Coordinates: 6020330..6020512 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0Q0DRU8
• Locus tag: Pta6605_RS26715
• Protein ID: WP_016981256.1
• Coordinates: 6019873..6020298 (-)
• Length: 142 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Pta6605_RS26700 (Pta6605_53750)	6016339..6017661	+	1323	WP_029240926.1	murein hydrolase activator EnvC	-
Pta6605_RS26705 (Pta6605_53760)	6017695..6019032	+	1338	WP_016981257.1	S41 family peptidase	-
Pta6605_RS26710 (Pta6605_53770)	6019036..6019818	+	783	WP_005745049.1	divergent polysaccharide deacetylase family protein	-
Pta6605_RS26715 (Pta6605_53780)	6019873..6020298	-	426	WP_016981256.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
Pta6605_RS26720 (Pta6605_53790)	6020330..6020512	-	183	WP_005781617.1	type II toxin-antitoxin system HicA family toxin	Toxin
Pta6605_RS26725	6020834..6021074	+	241	Protein_5284	serine protease	-
Pta6605_RS26730 (Pta6605_53800)	6021079..6021834	-	756	WP_004663214.1	ABC transporter substrate-binding protein	-
Pta6605_RS26735 (Pta6605_53810)	6022020..6022790	-	771	WP_002551458.1	imidazole glycerol phosphate synthase subunit HisF	-
Pta6605_RS26740 (Pta6605_53820)	6022810..6023547	-	738	WP_002551457.1	1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase	-
Pta6605_RS26745 (Pta6605_53830)	6023655..6023915	-	261	WP_016981255.1	DUF2164 domain-containing protein	-
Pta6605_RS26750 (Pta6605_53840)	6023920..6024558	-	639	WP_005745046.1	imidazole glycerol phosphate synthase subunit HisH	-
Pta6605_RS26755 (Pta6605_53850)	6024558..6025151	-	594	WP_002551454.1	imidazoleglycerol-phosphate dehydratase HisB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-58)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6877.97 Da
• Isoelectric Point: 10.6211

>T38462 WP_005781617.1 NZ_AP024464:c6020512-6020330 [Pseudomonas amygdali pv. tabaci]
MKCNEFRRWLQAQGAEFRAAKGSHFKVYLNGKATIFADHGSKEMHEGLRKSIIKQLGLKD

Nucleotide

• Length: 183 bp

>T38462 NZ_AP024464:c6020512-6020330 [Pseudomonas amygdali pv. tabaci]
ATGAAGTGCAACGAGTTTCGGCGATGGTTGCAGGCTCAAGGCGCTGAGTTCAGGGCTGCCAAGGGTAGTCATTTCAAGGT
TTACCTGAATGGTAAGGCAACCATCTTTGCAGACCATGGAAGCAAAGAAATGCACGAAGGGTTACGCAAGTCGATCATCA
AGCAGCTCGGCCTTAAGGATTGA

Antitoxin

Protein

• Length: 142 a.a.
• Molecular weight: 15783.24 Da
• Isoelectric Point: 5.2548

>AT38462 WP_016981256.1 NZ_AP024464:c6020298-6019873 [Pseudomonas amygdali pv. tabaci]
MYQYPLDLHREPTGVWLSCPDIPEMSASGDTLPEAFSEALDGMESALSLYVDQRRKIPQASVVPGHELLMRLPALTVAKI
MLWNSLLEEGVSRAELARRLGCTRQVVDRLVDFLHASKIEQVERALAELGRRITLSIERAA

Nucleotide

• Length: 426 bp

>AT38462 NZ_AP024464:c6020298-6019873 [Pseudomonas amygdali pv. tabaci]
ATGTATCAATATCCATTGGATCTACATCGGGAGCCGACAGGCGTTTGGCTGTCGTGTCCAGACATTCCCGAAATGAGCGC
CTCTGGCGACACCCTGCCTGAAGCATTTAGCGAAGCTCTTGACGGCATGGAATCGGCTCTATCGCTCTACGTCGATCAGC
GTCGCAAGATTCCCCAAGCCTCAGTCGTACCCGGCCATGAACTGTTGATGCGTTTGCCTGCGCTGACGGTTGCCAAAATC
ATGCTATGGAACAGCTTGTTGGAAGAGGGCGTTAGCCGTGCTGAGCTGGCGCGTCGCCTCGGTTGCACGCGGCAAGTGGT
GGATCGGCTTGTGGACTTTCTGCATGCCTCGAAAATCGAGCAGGTGGAGCGAGCGCTGGCTGAGCTTGGTCGGCGTATTA
CGTTGAGCATTGAGCGGGCCGCTTGA

Structures

Toxin

• AlphaFold DB: A0A7Z6Y3C5

Antitoxin

• AlphaFold DB: A0A0Q0DRU8