Detailed information of TA system TA038461

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 4321779..4322292
• Replicon: chromosome
• Accession: NZ_AP024464
• Organism: Pseudomonas amygdali pv. tabaci strain 6605

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: Pta6605_RS19080
• Protein ID: WP_004658391.1
• Coordinates: 4322008..4322292 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0N8T2X1
• Locus tag: Pta6605_RS19075
• Protein ID: WP_029241049.1
• Coordinates: 4321779..4322018 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Pta6605_RS19055 (Pta6605_38540)	4317888..4318673	+	786	WP_002552796.1	outer membrane protein OmpK	-
Pta6605_RS19060 (Pta6605_38550)	4318852..4319760	-	909	WP_016982380.1	DUF808 domain-containing protein	-
Pta6605_RS19065 (Pta6605_38560)	4319910..4320416	-	507	WP_002552794.1	Lrp/AsnC family transcriptional regulator	-
Pta6605_RS19070 (Pta6605_38570)	4320603..4321619	+	1017	WP_002552793.1	1-aminocyclopropane-1-carboxylate deaminase	-
Pta6605_RS19075 (Pta6605_38580)	4321779..4322018	+	240	WP_029241049.1	CopG family ribbon-helix-helix protein	Antitoxin
Pta6605_RS19080 (Pta6605_38590)	4322008..4322292	+	285	WP_004658391.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Pta6605_RS19085 (Pta6605_38600)	4322329..4323183	-	855	WP_016982382.1	LysR family transcriptional regulator	-
Pta6605_RS19090 (Pta6605_38610)	4323258..4324190	+	933	WP_016982383.1	DMT family transporter	-
Pta6605_RS19095 (Pta6605_38620)	4324221..4326149	-	1929	WP_010198401.1	methyl-accepting chemotaxis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-41)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10647.31 Da
• Isoelectric Point: 10.4249

>T38461 WP_004658391.1 NZ_AP024464:4322008-4322292 [Pseudomonas amygdali pv. tabaci]
MQVEWLKTALKNLDEEAAYIAQDNPAAAAAFVKAIQSSVTQLASFPAMGREGRIAGTREWPLPDLPYLIPYRIRSGRLQV
LRIFHTRRQSPPVW

Nucleotide

• Length: 285 bp

>T38461 NZ_AP024464:4322008-4322292 [Pseudomonas amygdali pv. tabaci]
ATGCAGGTTGAGTGGCTTAAAACGGCGCTAAAGAATCTGGATGAGGAGGCAGCGTATATCGCACAGGACAATCCAGCTGC
TGCCGCAGCTTTCGTGAAAGCAATTCAATCAAGCGTGACGCAGCTCGCGAGCTTTCCCGCCATGGGCCGGGAAGGACGGA
TTGCCGGAACCAGAGAATGGCCTCTGCCAGACCTGCCTTACCTGATTCCATATCGCATCCGTAGCGGCCGGCTACAGGTT
CTAAGGATTTTCCACACCAGAAGACAATCGCCCCCCGTGTGGTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8715.80 Da
• Isoelectric Point: 4.4354

>AT38461 WP_029241049.1 NZ_AP024464:4321779-4322018 [Pseudomonas amygdali pv. tabaci]
MSTMSLRLPDEMADTLAHLAKATGRSKSFLALDALREYLTREAWQIAEIQRAIEEADAGEFANTEDVKAVMDKWSGNAG

Nucleotide

• Length: 240 bp

>AT38461 NZ_AP024464:4321779-4322018 [Pseudomonas amygdali pv. tabaci]
ATGTCCACAATGTCTCTACGTCTGCCGGACGAAATGGCGGATACCCTTGCACACCTTGCAAAGGCGACCGGGCGCAGCAA
GTCATTTTTGGCCCTCGACGCGCTCCGCGAATACCTGACTCGCGAGGCATGGCAGATTGCCGAAATTCAGCGCGCGATTG
AAGAAGCCGACGCTGGCGAGTTCGCCAATACAGAGGACGTAAAAGCTGTCATGGACAAATGGTCTGGCAATGCAGGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A0N8T2X1