38460

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1825645..1826267 Replicon chromosome
Accession NZ_AP024464
Organism Pseudomonas amygdali pv. tabaci strain 6605

Toxin (Protein)


Gene name hicA Uniprot ID A0A658PBH1
Locus tag Pta6605_RS08170 Protein ID WP_003434313.1
Coordinates 1825645..1825827 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A193SSY5
Locus tag Pta6605_RS08175 Protein ID WP_024661723.1
Coordinates 1825863..1826267 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Pta6605_RS08160 (Pta6605_16420) 1821837..1823585 - 1749 WP_016980782.1 N-acetylglutaminylglutamine synthetase -
Pta6605_RS08165 (Pta6605_16430) 1823589..1825361 - 1773 WP_016980783.1 N-acetylglutaminylglutamine amidotransferase -
Pta6605_RS08170 (Pta6605_16440) 1825645..1825827 + 183 WP_003434313.1 type II toxin-antitoxin system HicA family toxin Toxin
Pta6605_RS08175 (Pta6605_16450) 1825863..1826267 + 405 WP_024661723.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Pta6605_RS08180 (Pta6605_16460) 1826284..1827363 - 1080 WP_016980785.1 lipocalin-like domain-containing protein -
Pta6605_RS08185 (Pta6605_16470) 1827353..1829833 - 2481 WP_016980787.1 ABC transporter permease -
Pta6605_RS08190 (Pta6605_16480) 1829833..1830501 - 669 WP_016980788.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6777.99 Da        Isoelectric Point: 10.6643

>T38460 WP_003434313.1 NZ_AP024464:1825645-1825827 [Pseudomonas amygdali pv. tabaci]
VQSRQLIKELEADGWILDRVSGSHHMFKHPEKLQTVPVPHPKKDLPFGTVRAIKKLAGLV

Download         Length: 183 bp

>T38460 NZ_AP024464:1825645-1825827 [Pseudomonas amygdali pv. tabaci]
GTGCAGAGCAGGCAATTGATAAAGGAGCTTGAAGCAGATGGATGGATTCTGGATCGTGTTTCAGGCAGTCACCATATGTT
CAAGCATCCTGAAAAACTTCAGACAGTCCCCGTGCCGCATCCCAAGAAAGACTTGCCATTCGGAACGGTGCGGGCCATCA
AAAAGCTTGCCGGGCTGGTTTAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14345.43 Da        Isoelectric Point: 5.1643

>AT38460 WP_024661723.1 NZ_AP024464:1825863-1826267 [Pseudomonas amygdali pv. tabaci]
MKYPMCIEWGSETTAFGIQIPDIPGAVTAGDTFEEAHAAAVEIAHIMLQEIAAGGGTIPKAGTVAEHARNADFAGMGWGM
IEIDVTPYLGKTEKVNVTLPGFVIKQIDRYVRDHSIKSRSTFLADAALEKLGRA

Download         Length: 405 bp

>AT38460 NZ_AP024464:1825863-1826267 [Pseudomonas amygdali pv. tabaci]
ATGAAATATCCAATGTGCATAGAATGGGGAAGCGAAACCACGGCATTTGGTATCCAGATTCCCGATATCCCAGGTGCCGT
AACCGCAGGCGATACGTTCGAGGAAGCCCACGCCGCGGCGGTGGAGATTGCTCATATCATGCTGCAGGAAATAGCAGCTG
GTGGTGGAACCATACCCAAGGCCGGCACTGTGGCCGAGCACGCCAGGAATGCCGATTTCGCCGGAATGGGCTGGGGCATG
ATCGAGATTGACGTAACGCCTTATCTTGGTAAGACGGAGAAGGTCAACGTCACACTGCCTGGTTTCGTGATCAAGCAGAT
CGATCGCTATGTACGGGATCACAGCATCAAGAGTCGTTCCACCTTCCTGGCCGACGCGGCGCTGGAAAAACTGGGCCGGG
CATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A658PBH1

Antitoxin

Source ID Structure
AlphaFold DB A0A193SSY5

References