Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapB(antitoxin)
Location 2709154..2709719 Replicon chromosome
Accession NZ_AP024463
Organism Arachnia rubra strain SK-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SK1NUM_RS12365 Protein ID WP_212322423.1
Coordinates 2709154..2709516 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SK1NUM_RS12370 Protein ID WP_212322425.1
Coordinates 2709513..2709719 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SK1NUM_RS12350 (SK1NUM_24670) 2706023..2707285 + 1263 WP_212322419.1 sugar ABC transporter substrate-binding protein -
SK1NUM_RS12355 (SK1NUM_24680) 2707396..2708229 + 834 WP_212327801.1 sugar ABC transporter permease -
SK1NUM_RS12360 (SK1NUM_24690) 2708222..2709067 + 846 WP_212322421.1 carbohydrate ABC transporter permease -
SK1NUM_RS12365 (SK1NUM_24700) 2709154..2709516 - 363 WP_212322423.1 VapC toxin family PIN domain ribonuclease Toxin
SK1NUM_RS12370 (SK1NUM_24710) 2709513..2709719 - 207 WP_212322425.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
SK1NUM_RS12375 (SK1NUM_24720) 2709942..2710988 - 1047 WP_212322428.1 glycoside hydrolase family 76 protein -
SK1NUM_RS12380 (SK1NUM_24730) 2711084..2711425 - 342 WP_212322431.1 Imm51 family immunity protein -
SK1NUM_RS12385 (SK1NUM_24740) 2711622..2713322 + 1701 WP_212327804.1 NAD-dependent malic enzyme -
SK1NUM_RS12390 (SK1NUM_24750) 2713492..2714073 + 582 WP_223927573.1 hypothetical protein -
SK1NUM_RS12395 (SK1NUM_24760) 2714316..2714711 - 396 WP_212322447.1 SdpI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13722.00 Da        Isoelectric Point: 6.8728

>T38456 WP_212322423.1 NZ_AP024463:c2709516-2709154 [Arachnia rubra]
VILVDTSVWIDHFRRSDLRLVRLLRGDEAGCHAMVIGELALSSMPARSVRMSYLENLHRFPSLQDDEMLHLVESRRLWGR
GLSLVDVNLLGAVLVVPGARLWTRDKRLKSMAEELEIAFE

Download         Length: 363 bp

>T38456 NZ_AP024463:c2709516-2709154 [Arachnia rubra]
GTGATCCTCGTCGACACCTCCGTCTGGATCGACCACTTTCGCCGCAGCGACCTGCGTTTGGTCCGTCTGCTGCGTGGCGA
CGAGGCGGGCTGTCACGCCATGGTGATCGGCGAGCTGGCGCTCAGTTCCATGCCCGCTCGCTCGGTGCGGATGTCCTACC
TGGAGAACCTGCACCGGTTTCCCAGCCTGCAGGACGACGAAATGTTGCACCTCGTGGAGTCCAGGCGCCTGTGGGGCCGC
GGCCTCAGCCTGGTGGACGTCAACCTGCTCGGCGCGGTCCTCGTGGTGCCAGGGGCGCGACTGTGGACCCGGGACAAGCG
TCTTAAGTCAATGGCGGAGGAGCTGGAGATCGCCTTCGAGTAG

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7390.36 Da        Isoelectric Point: 5.0807

>AT38456 WP_212322425.1 NZ_AP024463:c2709719-2709513 [Arachnia rubra]
MRTTVTLDDDLVSRAQELTGVKERSVLLREGLETLIRVESARRLAALGGAEPEAQASARNRDLGDLAK

Download         Length: 207 bp

>AT38456 NZ_AP024463:c2709719-2709513 [Arachnia rubra]
ATGAGAACCACGGTGACCTTGGACGATGACCTGGTGAGCCGCGCCCAGGAGCTCACTGGGGTCAAGGAGCGTTCCGTTCT
GCTCCGCGAGGGCCTGGAGACGCTGATCCGCGTTGAGAGTGCCCGGCGGCTGGCGGCACTGGGTGGCGCTGAGCCCGAGG
CGCAGGCGTCGGCGCGCAACCGGGACCTTGGAGACCTCGCCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References