Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 6299776..6300325 Replicon chromosome
Accession NZ_AP024452
Organism Luteitalea sp. TBR-22

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag TBR22_RS25940 Protein ID WP_239490751.1
Coordinates 6299776..6300120 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag TBR22_RS25945 Protein ID WP_239490752.1
Coordinates 6300134..6300325 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBR22_RS25910 (TBR22_51660) 6295647..6296174 + 528 WP_239490745.1 hypothetical protein -
TBR22_RS25915 (TBR22_A52110) 6296504..6296890 - 387 WP_239490746.1 PIN domain-containing protein -
TBR22_RS25920 (TBR22_51680) 6296887..6297177 - 291 WP_239490747.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
TBR22_RS25925 (TBR22_51690) 6297419..6297886 - 468 WP_239490748.1 DsrE/DsrF/DrsH-like family protein -
TBR22_RS25930 (TBR22_51700) 6297889..6298203 - 315 WP_239490749.1 TusE/DsrC/DsvC family sulfur relay protein -
TBR22_RS25935 (TBR22_51710) 6298318..6299574 - 1257 WP_239490750.1 FAD/NAD(P)-binding oxidoreductase -
TBR22_RS25940 (TBR22_51720) 6299776..6300120 - 345 WP_239490751.1 PIN domain-containing protein Toxin
TBR22_RS25945 (TBR22_51730) 6300134..6300325 - 192 WP_239490752.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
TBR22_RS25950 (TBR22_51740) 6300880..6302667 - 1788 WP_239490753.1 DEAD/DEAH box helicase -
TBR22_RS25955 (TBR22_51750) 6302780..6303382 + 603 WP_239490754.1 hypothetical protein -
TBR22_RS25960 (TBR22_51760) 6303289..6304713 - 1425 WP_239490755.1 hypothetical protein -
TBR22_RS25965 (TBR22_51770) 6304734..6304970 - 237 WP_239490756.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-109)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-47)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12409.36 Da        Isoelectric Point: 6.8446

>T38453 WP_239490751.1 NZ_AP024452:c6300120-6299776 [Luteitalea sp. TBR-22]
MILVDTSVWIDHLRRGDEELSALLDEGQVLVHPFVVGEIACGSLKRRADVVAHLQRLPAAPVATEAEVHHLLEREGLHGR
GLGWVDLHLLASARLAAVPLLTRDRALAGAARPR

Download         Length: 345 bp

>T38453 NZ_AP024452:c6300120-6299776 [Luteitalea sp. TBR-22]
ATGATCCTCGTCGACACGTCGGTCTGGATCGATCACCTGCGCCGCGGCGACGAGGAGCTCTCCGCCCTGCTCGACGAGGG
ACAGGTGCTCGTCCACCCGTTCGTCGTCGGCGAGATCGCGTGTGGTTCGTTGAAGCGGCGCGCCGACGTGGTGGCGCACC
TGCAGCGGCTGCCGGCCGCGCCGGTGGCCACCGAGGCCGAGGTGCATCACCTGCTCGAGCGCGAGGGCCTGCACGGCCGC
GGGCTCGGGTGGGTGGACCTCCATCTGCTGGCCTCCGCCCGCCTTGCCGCCGTCCCGCTTCTCACCCGGGATCGCGCTCT
GGCCGGAGCGGCGCGCCCGCGGTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 6842.91 Da        Isoelectric Point: 11.6072

>AT38453 WP_239490752.1 NZ_AP024452:c6300325-6300134 [Luteitalea sp. TBR-22]
MRTTMILDDALIEEARQLTGIAEKTALVHEGLRALVAREHAARLRRLAGSDPTAAAGPRRRPA

Download         Length: 192 bp

>AT38453 NZ_AP024452:c6300325-6300134 [Luteitalea sp. TBR-22]
ATGCGTACGACCATGATCCTGGACGATGCGTTGATCGAGGAGGCGCGTCAGCTGACGGGCATCGCGGAGAAGACGGCGCT
GGTGCACGAGGGCTTGCGCGCCCTGGTGGCACGCGAGCACGCCGCGCGCCTGCGTCGCCTGGCCGGCTCCGACCCCACGG
CGGCGGCCGGCCCGCGACGTCGCCCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References