Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3143900..3144543 Replicon chromosome
Accession NZ_AP024452
Organism Luteitalea sp. TBR-22

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag TBR22_RS12950 Protein ID WP_239493410.1
Coordinates 3143900..3144289 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag TBR22_RS12955 Protein ID WP_239493411.1
Coordinates 3144289..3144543 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBR22_RS12930 (TBR22_25780) 3140280..3140882 + 603 WP_239493406.1 OmpA family protein -
TBR22_RS12935 (TBR22_25790) 3140904..3141815 + 912 WP_239493407.1 tol-pal system protein YbgF -
TBR22_RS12940 (TBR22_25800) 3142071..3142562 + 492 WP_239493408.1 single-stranded DNA-binding protein -
TBR22_RS12945 (TBR22_25810) 3142668..3143648 + 981 WP_239493409.1 aldo/keto reductase -
TBR22_RS12950 (TBR22_25820) 3143900..3144289 - 390 WP_239493410.1 type II toxin-antitoxin system VapC family toxin Toxin
TBR22_RS12955 (TBR22_25830) 3144289..3144543 - 255 WP_239493411.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
TBR22_RS12960 (TBR22_25840) 3144581..3146272 - 1692 WP_239493491.1 phosphoenolpyruvate--protein phosphotransferase -
TBR22_RS12965 (TBR22_25850) 3146280..3146546 - 267 WP_239493412.1 HPr family phosphocarrier protein -
TBR22_RS12970 (TBR22_25860) 3146551..3146985 - 435 WP_239493413.1 PTS sugar transporter subunit IIA -
TBR22_RS12975 (TBR22_25870) 3147081..3147947 - 867 WP_239493414.1 RNase adapter RapZ -
TBR22_RS12980 (TBR22_25880) 3147944..3148909 - 966 WP_239493415.1 HPr(Ser) kinase/phosphatase -
TBR22_RS12985 (TBR22_25890) 3148926..3149498 - 573 WP_239493416.1 ribosome-associated translation inhibitor RaiA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13911.78 Da        Isoelectric Point: 4.9501

>T38452 WP_239493410.1 NZ_AP024452:c3144289-3143900 [Luteitalea sp. TBR-22]
MVIDTSALLAILQDEPERRALNEAIEAAAERVVSVASFVEASVVIEARYGLAGVRELDTFIDKAGITLAPVDVEQARLAR
AAFSRFGRGRHKAALNFGDCFTYALAASRGESVLFKGEDFAHTDLTPAR

Download         Length: 390 bp

>T38452 NZ_AP024452:c3144289-3143900 [Luteitalea sp. TBR-22]
ATGGTGATCGACACCTCGGCGCTGCTCGCCATCCTGCAGGACGAACCGGAGCGGCGGGCGTTGAACGAGGCCATCGAAGC
CGCCGCCGAGCGAGTCGTCTCGGTGGCGTCGTTCGTCGAGGCGTCCGTCGTCATCGAGGCGAGGTACGGGCTCGCCGGCG
TCCGCGAACTCGACACGTTCATCGACAAGGCCGGCATCACCCTGGCTCCAGTGGATGTCGAACAGGCGCGCCTGGCGCGT
GCGGCGTTCAGTCGCTTCGGACGGGGACGTCACAAGGCGGCGTTGAACTTCGGCGACTGCTTCACCTATGCGCTGGCTGC
GAGCCGGGGAGAGTCGGTGCTCTTCAAGGGCGAGGACTTCGCGCACACCGACCTCACCCCGGCGCGCTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9242.51 Da        Isoelectric Point: 9.2634

>AT38452 WP_239493411.1 NZ_AP024452:c3144543-3144289 [Luteitalea sp. TBR-22]
MALNIRNAEAERLAATLARLTGETKTEAVTRALEDRIARVRAERSGRRLADTLDAIAVRCASLPVRDRRPADEILGYDDA
GLPR

Download         Length: 255 bp

>AT38452 NZ_AP024452:c3144543-3144289 [Luteitalea sp. TBR-22]
ATGGCGCTGAACATCCGCAATGCCGAGGCCGAACGTCTGGCCGCGACCCTGGCCCGGCTCACCGGGGAGACCAAGACCGA
GGCCGTGACCAGGGCGCTCGAGGACCGCATCGCTCGCGTGCGCGCGGAGCGGAGCGGCAGGCGGCTCGCCGACACCCTGG
ATGCGATCGCCGTGCGGTGCGCCAGCCTGCCGGTGCGCGACCGGCGGCCCGCCGACGAGATCCTGGGATACGACGACGCG
GGGTTGCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References