Detailed information of TA system TA038450

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/GNAT-DUF1778
• Location: 2279554..2280341
• Replicon: chromosome
• Accession: NZ_AP024452
• Organism: Luteitalea sp. TBR-22

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: TBR22_RS09320
• Protein ID: WP_239492703.1
• Coordinates: 2279832..2280341 (+)
• Length: 170 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: -
• Locus tag: TBR22_RS09315
• Protein ID: WP_239492702.1
• Coordinates: 2279554..2279835 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TBR22_RS09300 (TBR22_18630)	2276264..2276722	-	459	WP_239492699.1	hypothetical protein	-
TBR22_RS09305 (TBR22_18640)	2277008..2278204	+	1197	WP_239492700.1	hypothetical protein	-
TBR22_RS09310 (TBR22_18650)	2278201..2279157	+	957	WP_239492701.1	VWA domain-containing protein	-
TBR22_RS09315 (TBR22_18660)	2279554..2279835	+	282	WP_239492702.1	DUF1778 domain-containing protein	Antitoxin
TBR22_RS09320 (TBR22_18670)	2279832..2280341	+	510	WP_239492703.1	GNAT family N-acetyltransferase	Toxin
TBR22_RS09325 (TBR22_18680)	2280850..2281200	+	351	WP_239492704.1	nucleotidyltransferase family protein	-
TBR22_RS09330 (TBR22_18690)	2281190..2281528	+	339	WP_239492705.1	DUF86 domain-containing protein	-
TBR22_RS09335 (TBR22_A18870)	2281676..2282764	+	1089	WP_239492706.1	tetratricopeptide repeat protein	-
TBR22_RS09340 (TBR22_A18880)	2282761..2283687	+	927	WP_239492707.1	VWA domain-containing protein	-
TBR22_RS09345 (TBR22_A18890)	2283718..2283981	-	264	WP_239492708.1	GIY-YIG nuclease family protein	-
TBR22_RS09350 (TBR22_18700)	2284565..2284888	-	324	WP_239492709.1	helix-turn-helix transcriptional regulator	-
TBR22_RS09355 (TBR22_18710)	2284885..2285244	-	360	WP_239492710.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (46-148)

Antitoxin

• Vibrio phage ICP1, Orf50 (12-86)

Sequences

Toxin

Protein

• Length: 170 a.a.
• Molecular weight: 18108.88 Da
• Isoelectric Point: 9.5927

>T38450 WP_239492703.1 NZ_AP024452:2279832-2280341 [Luteitalea sp. TBR-22]
MNRDADVGAPEHLDAHHDIAAFDSGTPDLDLWLKRRALTNEALGASRTYVVCASGRVVGFYALATGAVAHEAVTGRVRRN
MPDPIPVMVLARLAVDRAYQGRGLGRALLRDALLRTLQAAEIVGIRAVLVHALSPSAKQFYLQAGFTEAPVSPMTLLVTL
TDVAGRVRS

Nucleotide

• Length: 510 bp

>T38450 NZ_AP024452:2279832-2280341 [Luteitalea sp. TBR-22]
ATGAATCGGGACGCCGACGTGGGCGCTCCAGAGCACCTGGACGCACATCACGACATCGCGGCGTTCGATTCCGGCACGCC
CGATCTGGACCTCTGGTTGAAACGGCGCGCGTTGACCAACGAAGCGCTCGGCGCGTCCCGTACCTACGTCGTCTGCGCAT
CCGGTCGCGTGGTCGGCTTCTATGCCCTGGCCACCGGCGCCGTGGCCCACGAGGCCGTGACCGGGCGCGTGCGGCGGAAC
ATGCCGGATCCGATCCCCGTGATGGTGCTCGCGCGGCTGGCGGTGGACCGGGCCTACCAGGGCCGCGGGCTGGGGCGGGC
GTTGTTGCGCGACGCGCTGCTGCGCACCCTGCAGGCGGCCGAGATTGTGGGCATCCGCGCCGTGCTTGTCCACGCCCTCT
CGCCGTCGGCCAAGCAGTTCTACCTGCAGGCGGGTTTCACGGAGGCCCCGGTGAGTCCGATGACGCTGCTGGTGACGCTG
ACTGACGTGGCAGGTCGCGTACGTTCTTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10359.84 Da
• Isoelectric Point: 10.0050

>AT38450 WP_239492702.1 NZ_AP024452:2279554-2279835 [Luteitalea sp. TBR-22]
MANAASCPRTSISLRIPDDQRALIDRAAEASGKDRTAFMLDAATREATTVLLDQRYFRLDADAWATFTALLDARPTPNPR
LKKLLATKAPWER

Nucleotide

• Length: 282 bp

>AT38450 NZ_AP024452:2279554-2279835 [Luteitalea sp. TBR-22]
ATGGCGAACGCCGCATCCTGCCCGCGCACGAGCATCAGCCTCCGCATTCCCGACGACCAGCGCGCTCTGATCGACCGCGC
CGCTGAGGCGTCCGGCAAGGACCGCACCGCGTTCATGCTCGACGCCGCGACCCGCGAGGCGACGACCGTGCTGCTCGATC
AACGCTATTTCCGGCTGGACGCGGATGCGTGGGCCACGTTCACGGCCCTGCTGGATGCGCGGCCGACGCCGAACCCGCGG
CTCAAGAAACTGCTGGCTACCAAAGCCCCTTGGGAGCGATGA