Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1578618..1579153 Replicon chromosome
Accession NZ_AP024414
Organism Haemophilus influenzae strain TA8730

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JUD77_RS07905 Protein ID WP_071163272.1
Coordinates 1578618..1578881 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JUD77_RS07910 Protein ID WP_071163271.1
Coordinates 1578878..1579153 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JUD77_RS07885 1574315..1574488 - 174 WP_005657572.1 DUF5363 domain-containing protein -
JUD77_RS07890 1574485..1576455 - 1971 WP_103708111.1 tRNA(Met) cytidine acetyltransferase TmcA -
JUD77_RS07895 1576460..1576801 - 342 WP_040033872.1 SirB2 family protein -
JUD77_RS07900 1576864..1578534 - 1671 WP_005650218.1 energy-dependent translational throttle protein EttA -
JUD77_RS07905 1578618..1578881 - 264 WP_071163272.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
JUD77_RS07910 1578878..1579153 - 276 WP_071163271.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JUD77_RS07915 1579504..1580124 + 621 WP_005650213.1 zinc transporter binding subunit ZevA -
JUD77_RS07920 1580127..1581095 + 969 WP_071163270.1 zinc transporter permease subunit ZevB -
JUD77_RS07930 1581710..1583749 + 2040 WP_203620488.1 excinuclease ABC subunit B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10201.90 Da        Isoelectric Point: 7.8978

>T38445 WP_071163272.1 NZ_AP024414:c1578881-1578618 [Haemophilus influenzae]
MISVSGEYKREFKKHIPLLINSPEYIEVMYCLLNSLPLPEKYKDHALTGNWKGWRDCHIKNDLVLIYKVVGDEIRLARLN
THSEIFG

Download         Length: 264 bp

>T38445 NZ_AP024414:c1578881-1578618 [Haemophilus influenzae]
ATGATTTCAGTGAGTGGGGAATATAAAAGAGAATTTAAAAAACATATTCCTCTTCTTATAAATAGTCCAGAATATATTGA
AGTTATGTATTGTCTTTTGAATAGCTTACCATTGCCAGAAAAATATAAAGATCATGCTTTAACTGGAAATTGGAAAGGTT
GGAGAGATTGCCATATAAAGAATGATCTTGTGCTTATTTATAAAGTGGTGGGAGATGAAATAAGGCTGGCTCGTCTTAAT
ACTCATTCAGAAATTTTTGGTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10277.84 Da        Isoelectric Point: 6.0646

>AT38445 WP_071163271.1 NZ_AP024414:c1579153-1578878 [Haemophilus influenzae]
MAAVSFRVPDETKNMAFEVIKSYGLSPTQALNMFLAQIAKTKAIPVSLDYQTEQMPNSKTIMAMAELDNHHGHEYKTLEE
FHQAMLAEMKS

Download         Length: 276 bp

>AT38445 NZ_AP024414:c1579153-1578878 [Haemophilus influenzae]
ATGGCTGCAGTTAGTTTTCGAGTACCTGATGAAACTAAAAATATGGCGTTTGAAGTGATTAAAAGTTACGGTCTTTCCCC
AACTCAAGCACTTAATATGTTTTTAGCTCAAATAGCTAAAACGAAAGCGATTCCAGTATCACTAGATTATCAAACTGAAC
AGATGCCTAACTCAAAAACGATAATGGCTATGGCAGAGTTAGATAATCATCATGGGCATGAATACAAAACATTGGAGGAA
TTCCATCAAGCGATGCTAGCGGAGATGAAATCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References