38443

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 579788..580125 Replicon chromosome
Accession NZ_AP024414
Organism Haemophilus influenzae strain TA8730

Toxin (Protein)


Gene name VapD Uniprot ID -
Locus tag JUD77_RS02865 Protein ID WP_071162882.1
Coordinates 579988..580125 (+) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag JUD77_RS02860 Protein ID WP_005649350.1
Coordinates 579788..579979 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JUD77_RS02840 575997..576980 + 984 WP_071162884.1 DNA polymerase III subunit delta' -
JUD77_RS02845 577035..577817 + 783 WP_071162883.1 YchF/TatD family DNA exonuclease -
JUD77_RS02850 577844..578368 + 525 WP_005652096.1 DUF1523 family protein -
JUD77_RS02855 578419..579717 + 1299 Protein_540 HlyC/CorC family transporter -
JUD77_RS02860 579788..579979 + 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
JUD77_RS02865 579988..580125 + 138 WP_071162882.1 virulence-associated protein D Toxin
JUD77_RS02870 580218..580748 + 531 WP_005686915.1 hypothetical protein -
JUD77_RS02875 580820..582319 + 1500 WP_071162881.1 fused PTS fructose transporter subunit IIA/HPr protein -
JUD77_RS02880 582321..583262 + 942 WP_071162880.1 1-phosphofructokinase -
JUD77_RS02885 583264..584937 + 1674 WP_203620539.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5270.90 Da        Isoelectric Point: 4.2907

>T38443 WP_071162882.1 NZ_AP024414:579988-580125 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAFLIEQWSNFTDFIRN

Download         Length: 138 bp

>T38443 NZ_AP024414:579988-580125 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAGGGTGTTCAACAGGCTTATACAGA
CATTGGCGCTTTTCTTATTGAGCAATGGTCTAATTTTACTGATTTTATACGAAATTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT38443 WP_005649350.1 NZ_AP024414:579788-579979 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT38443 NZ_AP024414:579788-579979 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGACATTTATCGATTAT
CTCACCTGCTTGAAGATCCCGAAGCTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References