Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4641197..4642770 Replicon chromosome
Accession NZ_AP024402
Organism Aeromonas caviae strain KAM376

Toxin (Protein)


Gene name hipA Uniprot ID A0A2R7QC79
Locus tag JSX26_RS21855 Protein ID WP_042013336.1
Coordinates 4641197..4642516 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1Q8D8F6
Locus tag JSX26_RS21860 Protein ID WP_042013334.1
Coordinates 4642516..4642770 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JSX26_RS21840 4637100..4637864 + 765 WP_010672275.1 ATP-binding cassette domain-containing protein -
JSX26_RS21845 4637896..4638798 + 903 WP_203765284.1 ABC transporter substrate-binding protein -
JSX26_RS21850 4638795..4640777 + 1983 WP_203763685.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -
JSX26_RS21855 4641197..4642516 - 1320 WP_042013336.1 type II toxin-antitoxin system HipA family toxin Toxin
JSX26_RS21860 4642516..4642770 - 255 WP_042013334.1 helix-turn-helix domain-containing protein Antitoxin
JSX26_RS21865 4642940..4643368 - 429 WP_203763688.1 DUF86 domain-containing protein -
JSX26_RS21870 4643361..4643810 - 450 WP_075112290.1 nucleotidyltransferase domain-containing protein -
JSX26_RS21875 4644256..4644873 + 618 WP_107683433.1 recombinase family protein -
JSX26_RS21880 4644870..4645193 - 324 WP_101778626.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4641197..4657968 16771


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49396.41 Da        Isoelectric Point: 7.0149

>T38439 WP_042013336.1 NZ_AP024402:c4642516-4641197 [Aeromonas caviae]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDGELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITEIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDAISSTILEGLKARSARLIKGWD

Download         Length: 1320 bp

>T38439 NZ_AP024402:c4642516-4641197 [Aeromonas caviae]
ATGGCCAATCTGGCTGTCTACATGAACGGCTATCGGGTAGGCACATTCACCAAAACTACCAGCGGCGCCCATCAGTTTCA
GTACCATGAGTCATGGCTGGCACAACCGGGCAGCCGTCCCATCTCACTTTCCATGCCATTGCGCCATCAGGCCTACCGGG
GCGATGAAGCCTATAACTTCTTCGACAACCTGCTGCCAGATAATACGGAGGTGAGGAACAGGGTTGTAGCACGCTATCAA
GCGGCATCAACTCAGCCCTTCGATCTGCTCAGTTGCATTGGCCAGGATAGCGTAGGGGCATTACAGCTGGTTACCGAAGG
GCACGACGTTCCAGATGTCAGGCGAATCGACTACAAAGCACTTTCCGATGGCGAGCTCGAGCAGATCCTGACCAGCTACA
AATCAGGAATCCCTTTGGGGATGGTCAGGGAGCAAGAGGAGTTCCGGATCTCTATCGCCGGAGCGCAAGAAAAGACAGCG
CTGCTCTATCTCGATGGCCGTTGGTACTTGCCACTCAACGCAACGCCGACAACCCACATTATCAAACTCCCTATTGGCAA
GATTGAAAGCCACTCCTACTCGATAGACCTCTCCCAGAGCGTAGAAAACGAATATCTCTGCACTCTGATTGCCAAGGAGT
TTGGTCTACCCGTACCTCACTGCTTCATGATGCAGGTTGGCCAGGTCAAAGCACTGGCTGTGGAACGCTTCGACAGACGT
TACGCTGCCGATCGCAGTTGGATCATGCGCCTTCCCCAAGAAGATTTCTGTCAGGTATTGAATGTTCCGTCAGCACGGAA
ATACGAGAGTCATGGAGGACCAGGGATCACTGAAATCATGAAAACCTTGTTGGGCTCTGCGACACCAGAACAGGATCGCT
ACCTGTTCATGAAATCTCAGGTCCTGTTCTGGCTGCTGGCAGCCACCGATGGCCATGCAAAGAACTTCTCGGTCTTTATT
GAACCGGAAGGACGTTTTCGCCTGACCCCTTTTTACGACATCCTATCTGTCTATCCAGTGTTTGGCGGCCGAGGCCTCAA
CCGAAGGGACGCCAAGCTCGCTATGGGCCTAGCAAGCAGCAAGGGAAAGAAATACGCCATTGAGCAGATATTCCCGCGTC
ATTTCTTCCAAACGGCAAAAGCTGTGGGATTTGAGCGTTCTGCTATGGAAGAGATCCTGACAGAACTGGCCAACTCCGTT
GATGATGTTATTGAGCGTGTTACCCAGCAATTGCCAGCGGGCTTCCCCGATGCCATCAGCAGCACCATTCTAGAGGGCCT
AAAAGCCCGCTCAGCCAGGCTGATAAAGGGCTGGGATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9323.64 Da        Isoelectric Point: 7.9834

>AT38439 WP_042013334.1 NZ_AP024402:c4642770-4642516 [Aeromonas caviae]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILASLELSLDIKPRNESSESPASGW
KEEW

Download         Length: 255 bp

>AT38439 NZ_AP024402:c4642770-4642516 [Aeromonas caviae]
ATGAAAGTAACCAGCGCCAAACAGCTGAGCGCCTGTATCAAGGATGCCAGGCTTTCTCAAAAGCTCTCTCAAGGCAAAGT
GGCCGAGAAAGTGGGGATTAGGCAAGACACAGTCTCCAGCTTCGAACTCAATCCTGAGTCCACCAAGCTGGAAACCCTGT
TCAAGATCCTCGCATCACTCGAATTGTCACTGGACATCAAACCCCGCAATGAGTCATCCGAGAGTCCGGCATCGGGCTGG
AAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R7QC79

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8D8F6

References