Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 3993457..3994004 Replicon chromosome
Accession NZ_AP024354
Organism Pseudomonas alcaligenes strain KAM426

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JUH08_RS19275 Protein ID WP_061194819.1
Coordinates 3993729..3994004 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JUH08_RS19270 Protein ID WP_061194820.1
Coordinates 3993457..3993729 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JUH08_RS19240 3990227..3990745 - 519 WP_203792471.1 peptide-methionine (S)-S-oxide reductase MsrA -
JUH08_RS19245 3990858..3991082 - 225 Protein_3777 helix-turn-helix domain-containing protein -
JUH08_RS19250 3991368..3992138 + 771 WP_061198833.1 DUF2807 domain-containing protein -
JUH08_RS19255 3992158..3992427 + 270 WP_061194823.1 hypothetical protein -
JUH08_RS19260 3992443..3992892 + 450 WP_061199210.1 hypothetical protein -
JUH08_RS19265 3992889..3993473 + 585 WP_061194821.1 hypothetical protein -
JUH08_RS19270 3993457..3993729 + 273 WP_061194820.1 ribbon-helix-helix domain-containing protein Antitoxin
JUH08_RS19275 3993729..3994004 + 276 WP_061194819.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JUH08_RS19280 3994006..3994833 + 828 WP_061194818.1 hypothetical protein -
JUH08_RS19285 3994847..3995089 + 243 WP_203787088.1 hypothetical protein -
JUH08_RS19290 3995144..3995389 + 246 WP_061194816.1 hypothetical protein -
JUH08_RS19295 3995564..3996766 + 1203 WP_203788698.1 hypothetical protein -
JUH08_RS19300 3996751..3998292 + 1542 WP_203788700.1 Hsp70 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island sul1 / blaIMP-1 - 3786007..4015023 229016


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-47)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10673.22 Da        Isoelectric Point: 7.2020

>T38435 WP_061194819.1 NZ_AP024354:3993729-3994004 [Pseudomonas alcaligenes]
MELKWTSKALSDLARLYEFLAAVNQPAAARTVQQLTAAPTTLLTNPRIGERLEEFDPRDVRRILVGHYEMRYEIADSTIY
LLRLWHTREDR

Download         Length: 276 bp

>T38435 NZ_AP024354:3993729-3994004 [Pseudomonas alcaligenes]
ATGGAGTTGAAGTGGACGAGCAAGGCCCTATCCGATCTGGCCCGCCTCTATGAGTTCCTTGCAGCGGTGAACCAGCCCGC
TGCGGCGCGCACAGTGCAGCAGCTCACCGCAGCGCCGACGACGCTGCTGACCAACCCGCGCATCGGCGAGCGGCTGGAAG
AGTTCGATCCGCGCGACGTGCGACGGATTCTGGTCGGGCACTACGAGATGCGCTACGAAATAGCAGACTCCACCATCTAC
CTGCTGCGCCTGTGGCATACACGCGAGGATCGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10054.25 Da        Isoelectric Point: 4.8616

>AT38435 WP_061194820.1 NZ_AP024354:3993457-3993729 [Pseudomonas alcaligenes]
MAATAKTRSVTAHVPVELAERVDEIAERLERSKNWIVKQALSAWIDQEEERSRLTREALADVDAGRVIDHQAVQAWADSL
STDTPLPVPH

Download         Length: 273 bp

>AT38435 NZ_AP024354:3993457-3993729 [Pseudomonas alcaligenes]
ATGGCCGCAACAGCTAAAACCCGATCCGTCACCGCCCACGTCCCTGTAGAGCTGGCCGAACGTGTTGATGAGATTGCCGA
GCGCCTGGAGCGCTCCAAGAACTGGATCGTCAAGCAAGCCCTGTCCGCCTGGATCGACCAGGAAGAAGAGCGCAGCCGCC
TGACCCGCGAGGCTCTGGCCGATGTGGATGCCGGCCGCGTGATCGACCATCAGGCCGTCCAGGCCTGGGCCGACAGCCTG
AGCACAGACACCCCGCTGCCGGTACCGCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References