Detailed information of TA system TA038434

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 3870205..3870752
• Replicon: chromosome
• Accession: NZ_AP024354
• Organism: Pseudomonas alcaligenes strain KAM426

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: JUH08_RS18620
• Protein ID: WP_116803468.1
• Coordinates: 3870205..3870480 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JUH08_RS18625
• Protein ID: WP_061194820.1
• Coordinates: 3870480..3870752 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JUH08_RS18590	3865381..3865716	-	336	WP_000741275.1	hypothetical protein	-
JUH08_RS18595	3865731..3866066	-	336	WP_203788597.1	helix-turn-helix domain-containing protein	-
JUH08_RS18600	3866047..3866424	-	378	WP_203788600.1	type II toxin-antitoxin system RelE/ParE family toxin	-
JUH08_RS18605	3866616..3867218	+	603	WP_010465829.1	recombinase family protein	-
JUH08_RS18610	3867202..3869889	+	2688	Protein_3650	Tn3 family transposase	-
JUH08_RS18615	3869939..3870202	-	264	WP_171953601.1	hypothetical protein	-
JUH08_RS18620	3870205..3870480	-	276	WP_116803468.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JUH08_RS18625	3870480..3870752	-	273	WP_061194820.1	ribbon-helix-helix domain-containing protein	Antitoxin
JUH08_RS18630	3870736..3871320	-	585	WP_061194821.1	hypothetical protein	-
JUH08_RS18635	3871317..3871766	-	450	WP_061199210.1	hypothetical protein	-
JUH08_RS18640	3871782..3872051	-	270	WP_061194823.1	hypothetical protein	-
JUH08_RS18645	3872071..3872841	-	771	WP_061198833.1	DUF2807 domain-containing protein	-
JUH08_RS18650	3873125..3874495	+	1371	Protein_3658	DDE-type integrase/transposase/recombinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	sul1 / blaIMP-1	-	3786007..4015023	229016

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (10-47)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10673.22 Da
• Isoelectric Point: 7.2022

>T38434 WP_116803468.1 NZ_AP024354:c3870480-3870205 [Pseudomonas alcaligenes]
MELKWTSKALSDLARLYEFLAAVNQPAAARTVQQLTAAPTTLLTNPRIGERLEEFDPRDVRRILVGHYEMRYEIEGSTIY
LLRLWHTREDR

Nucleotide

• Length: 276 bp

>T38434 NZ_AP024354:c3870480-3870205 [Pseudomonas alcaligenes]
ATGGAGTTGAAGTGGACGAGCAAGGCCCTATCCGATCTGGCCCGCCTCTATGAGTTCCTTGCAGCGGTGAACCAGCCCGC
TGCGGCGCGCACAGTGCAGCAGCTCACCGCAGCGCCGACGACGCTGCTGACCAACCCGCGCATCGGCGAGCGGCTGGAAG
AGTTCGATCCGCGCGACGTGCGACGGATTCTGGTCGGGCACTACGAGATGCGCTACGAAATCGAAGGCTCCACCATCTAC
CTGCTGCGCCTGTGGCACACCCGCGAGGATCGCTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10054.25 Da
• Isoelectric Point: 4.8616

>AT38434 WP_061194820.1 NZ_AP024354:c3870752-3870480 [Pseudomonas alcaligenes]
MAATAKTRSVTAHVPVELAERVDEIAERLERSKNWIVKQALSAWIDQEEERSRLTREALADVDAGRVIDHQAVQAWADSL
STDTPLPVPH

Nucleotide

• Length: 273 bp

>AT38434 NZ_AP024354:c3870752-3870480 [Pseudomonas alcaligenes]
ATGGCCGCAACAGCTAAAACCCGATCCGTCACCGCCCACGTCCCTGTAGAGCTGGCCGAACGTGTTGATGAGATTGCCGA
GCGCCTGGAGCGCTCCAAGAACTGGATCGTCAAGCAAGCCCTGTCCGCCTGGATCGACCAGGAAGAAGAGCGCAGCCGCC
TGACCCGCGAGGCTCTGGCCGATGTGGATGCCGGCCGCGTGATCGACCATCAGGCCGTCCAGGCCTGGGCCGACAGCCTG
AGCACAGACACCCCGCTGCCGGTACCGCACTGA