Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 3870205..3870752 Replicon chromosome
Accession NZ_AP024354
Organism Pseudomonas alcaligenes strain KAM426

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JUH08_RS18620 Protein ID WP_116803468.1
Coordinates 3870205..3870480 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JUH08_RS18625 Protein ID WP_061194820.1
Coordinates 3870480..3870752 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JUH08_RS18590 3865381..3865716 - 336 WP_000741275.1 hypothetical protein -
JUH08_RS18595 3865731..3866066 - 336 WP_203788597.1 helix-turn-helix domain-containing protein -
JUH08_RS18600 3866047..3866424 - 378 WP_203788600.1 type II toxin-antitoxin system RelE/ParE family toxin -
JUH08_RS18605 3866616..3867218 + 603 WP_010465829.1 recombinase family protein -
JUH08_RS18610 3867202..3869889 + 2688 Protein_3650 Tn3 family transposase -
JUH08_RS18615 3869939..3870202 - 264 WP_171953601.1 hypothetical protein -
JUH08_RS18620 3870205..3870480 - 276 WP_116803468.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JUH08_RS18625 3870480..3870752 - 273 WP_061194820.1 ribbon-helix-helix domain-containing protein Antitoxin
JUH08_RS18630 3870736..3871320 - 585 WP_061194821.1 hypothetical protein -
JUH08_RS18635 3871317..3871766 - 450 WP_061199210.1 hypothetical protein -
JUH08_RS18640 3871782..3872051 - 270 WP_061194823.1 hypothetical protein -
JUH08_RS18645 3872071..3872841 - 771 WP_061198833.1 DUF2807 domain-containing protein -
JUH08_RS18650 3873125..3874495 + 1371 Protein_3658 DDE-type integrase/transposase/recombinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island sul1 / blaIMP-1 - 3786007..4015023 229016


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-47)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10673.22 Da        Isoelectric Point: 7.2022

>T38434 WP_116803468.1 NZ_AP024354:c3870480-3870205 [Pseudomonas alcaligenes]
MELKWTSKALSDLARLYEFLAAVNQPAAARTVQQLTAAPTTLLTNPRIGERLEEFDPRDVRRILVGHYEMRYEIEGSTIY
LLRLWHTREDR

Download         Length: 276 bp

>T38434 NZ_AP024354:c3870480-3870205 [Pseudomonas alcaligenes]
ATGGAGTTGAAGTGGACGAGCAAGGCCCTATCCGATCTGGCCCGCCTCTATGAGTTCCTTGCAGCGGTGAACCAGCCCGC
TGCGGCGCGCACAGTGCAGCAGCTCACCGCAGCGCCGACGACGCTGCTGACCAACCCGCGCATCGGCGAGCGGCTGGAAG
AGTTCGATCCGCGCGACGTGCGACGGATTCTGGTCGGGCACTACGAGATGCGCTACGAAATCGAAGGCTCCACCATCTAC
CTGCTGCGCCTGTGGCACACCCGCGAGGATCGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10054.25 Da        Isoelectric Point: 4.8616

>AT38434 WP_061194820.1 NZ_AP024354:c3870752-3870480 [Pseudomonas alcaligenes]
MAATAKTRSVTAHVPVELAERVDEIAERLERSKNWIVKQALSAWIDQEEERSRLTREALADVDAGRVIDHQAVQAWADSL
STDTPLPVPH

Download         Length: 273 bp

>AT38434 NZ_AP024354:c3870752-3870480 [Pseudomonas alcaligenes]
ATGGCCGCAACAGCTAAAACCCGATCCGTCACCGCCCACGTCCCTGTAGAGCTGGCCGAACGTGTTGATGAGATTGCCGA
GCGCCTGGAGCGCTCCAAGAACTGGATCGTCAAGCAAGCCCTGTCCGCCTGGATCGACCAGGAAGAAGAGCGCAGCCGCC
TGACCCGCGAGGCTCTGGCCGATGTGGATGCCGGCCGCGTGATCGACCATCAGGCCGTCCAGGCCTGGGCCGACAGCCTG
AGCACAGACACCCCGCTGCCGGTACCGCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References