Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2676124..2676671 Replicon chromosome
Accession NZ_AP024354
Organism Pseudomonas alcaligenes strain KAM426

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JUH08_RS12830 Protein ID WP_061194819.1
Coordinates 2676124..2676399 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JUH08_RS12835 Protein ID WP_061194820.1
Coordinates 2676399..2676671 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JUH08_RS12800 2672364..2672894 + 531 WP_203787082.1 hypothetical protein -
JUH08_RS12805 2672858..2673826 - 969 WP_203787084.1 class I SAM-dependent methyltransferase -
JUH08_RS12810 2673951..2674718 + 768 WP_203787086.1 cation:proton antiporter -
JUH08_RS12815 2674739..2674984 - 246 WP_061194816.1 hypothetical protein -
JUH08_RS12820 2675039..2675281 - 243 WP_203787088.1 hypothetical protein -
JUH08_RS12825 2675295..2676122 - 828 WP_061194818.1 hypothetical protein -
JUH08_RS12830 2676124..2676399 - 276 WP_061194819.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JUH08_RS12835 2676399..2676671 - 273 WP_061194820.1 ribbon-helix-helix domain-containing protein Antitoxin
JUH08_RS12840 2676655..2677239 - 585 WP_061194821.1 hypothetical protein -
JUH08_RS12845 2677236..2677685 - 450 WP_061199210.1 hypothetical protein -
JUH08_RS12850 2677701..2677970 - 270 WP_061194823.1 hypothetical protein -
JUH08_RS12855 2677990..2678760 - 771 WP_061198833.1 DUF2807 domain-containing protein -
JUH08_RS12860 2679046..2679270 + 225 Protein_2517 helix-turn-helix domain-containing protein -
JUH08_RS12865 2679383..2679901 + 519 WP_203792471.1 peptide-methionine (S)-S-oxide reductase MsrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2674739..2697769 23030


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-47)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10673.22 Da        Isoelectric Point: 7.2020

>T38432 WP_061194819.1 NZ_AP024354:c2676399-2676124 [Pseudomonas alcaligenes]
MELKWTSKALSDLARLYEFLAAVNQPAAARTVQQLTAAPTTLLTNPRIGERLEEFDPRDVRRILVGHYEMRYEIADSTIY
LLRLWHTREDR

Download         Length: 276 bp

>T38432 NZ_AP024354:c2676399-2676124 [Pseudomonas alcaligenes]
ATGGAGTTGAAGTGGACGAGCAAGGCCCTATCCGATCTGGCCCGCCTCTATGAGTTCCTTGCAGCGGTGAACCAGCCCGC
TGCGGCGCGCACAGTGCAGCAGCTCACCGCAGCGCCGACGACGCTGCTGACCAACCCGCGCATCGGCGAGCGGCTGGAAG
AGTTCGATCCGCGCGACGTGCGACGGATTCTGGTCGGGCACTACGAGATGCGCTACGAAATAGCAGACTCCACCATCTAC
CTGCTGCGCCTGTGGCATACACGCGAGGATCGCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10054.25 Da        Isoelectric Point: 4.8616

>AT38432 WP_061194820.1 NZ_AP024354:c2676671-2676399 [Pseudomonas alcaligenes]
MAATAKTRSVTAHVPVELAERVDEIAERLERSKNWIVKQALSAWIDQEEERSRLTREALADVDAGRVIDHQAVQAWADSL
STDTPLPVPH

Download         Length: 273 bp

>AT38432 NZ_AP024354:c2676671-2676399 [Pseudomonas alcaligenes]
ATGGCCGCAACAGCTAAAACCCGATCCGTCACCGCCCACGTCCCTGTAGAGCTGGCCGAACGTGTTGATGAGATTGCCGA
GCGCCTGGAGCGCTCCAAGAACTGGATCGTCAAGCAAGCCCTGTCCGCCTGGATCGACCAGGAAGAAGAGCGCAGCCGCC
TGACCCGCGAGGCTCTGGCCGATGTGGATGCCGGCCGCGTGATCGACCATCAGGCCGTCCAGGCCTGGGCCGACAGCCTG
AGCACAGACACCCCGCTGCCGGTACCGCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References