Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1464415..1465632 Replicon chromosome
Accession NZ_AP024354
Organism Pseudomonas alcaligenes strain KAM426

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag JUH08_RS07085 Protein ID WP_203791758.1
Coordinates 1464880..1465632 (+) Length 251 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag JUH08_RS07080 Protein ID WP_203791757.1
Coordinates 1464415..1464786 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JUH08_RS07060 1459840..1460919 - 1080 WP_203791753.1 ACR3 family arsenite efflux transporter -
JUH08_RS07065 1461025..1461807 + 783 WP_203791754.1 metalloregulator ArsR/SmtB family transcription factor -
JUH08_RS07070 1461864..1462868 + 1005 WP_203791755.1 ArsJ-associated glyceraldehyde-3-phosphate dehydrogenase -
JUH08_RS07075 1462878..1464101 + 1224 WP_203791756.1 organoarsenical effux MFS transporter ArsJ -
JUH08_RS07080 1464415..1464786 + 372 WP_203791757.1 DUF2384 domain-containing protein Antitoxin
JUH08_RS07085 1464880..1465632 + 753 WP_203791758.1 RES family NAD+ phosphorylase Toxin
JUH08_RS07090 1465633..1466097 - 465 WP_203791759.1 copper chaperone PCu(A)C -
JUH08_RS07095 1466596..1467009 + 414 WP_021701970.1 sel1 repeat family protein -
JUH08_RS07100 1467190..1468551 + 1362 WP_203792355.1 DNA recombination protein RmuC -
JUH08_RS07105 1468553..1469809 - 1257 WP_203791760.1 MgtC/SapB family protein -
JUH08_RS07110 1469878..1470576 - 699 WP_203791761.1 pirin-like bicupin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(64-206)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 251 a.a.        Molecular weight: 28321.28 Da        Isoelectric Point: 7.0302

>T38430 WP_203791758.1 NZ_AP024354:1464880-1465632 [Pseudomonas alcaligenes]
MDIWQACAGVEQIIPLRGRLVRLVENQGQVATLQLVDTLEEQALLEQLLESSKPPLPPGDEPLHYLLRTPFRYPPLRWGS
RFGRRHEPSLFYAACRLETAMAETAFYRFVLWYGMVEPPPSGRILSEHSSFEARYQVQRGVRLQLPPFDGHRALLTHRSD
YRATHSLGSAMREAGVEAFEYPSARCPQGGNNVALYAPTAFSEKRPRNLQPWLCETTAGYVAFKNAQAPDTPRLYALDLY
LEDGVLPQPP

Download         Length: 753 bp

>T38430 NZ_AP024354:1464880-1465632 [Pseudomonas alcaligenes]
ATGGATATCTGGCAGGCCTGTGCCGGCGTAGAGCAGATCATTCCCCTGCGCGGCCGCCTGGTGCGCCTGGTCGAGAACCA
GGGCCAGGTGGCGACTCTGCAGCTGGTGGATACGCTGGAGGAGCAGGCGCTGCTCGAACAGTTGCTGGAGAGCAGCAAGC
CGCCGCTGCCGCCCGGTGACGAGCCGCTGCACTACCTGTTGCGCACGCCGTTTCGCTACCCGCCGCTGCGCTGGGGCTCG
CGTTTCGGCCGGCGCCATGAGCCGAGCCTGTTCTACGCCGCCTGCCGGCTGGAGACGGCGATGGCCGAGACCGCCTTCTA
TCGTTTCGTGCTGTGGTACGGCATGGTCGAGCCGCCGCCGAGCGGGCGCATCCTTTCCGAGCATTCGTCCTTCGAGGCGC
GCTACCAGGTGCAGCGCGGGGTGCGCCTGCAGCTACCGCCATTCGACGGCCATCGCGCGCTGCTGACCCATCGCAGTGAC
TATCGCGCCACCCACAGCCTGGGAAGCGCGATGCGCGAAGCGGGGGTGGAAGCGTTCGAGTATCCCTCGGCGCGCTGCCC
GCAGGGGGGCAACAACGTTGCCCTGTATGCGCCGACGGCGTTCAGCGAGAAGCGGCCGCGCAACCTGCAGCCGTGGCTAT
GCGAAACCACCGCAGGCTACGTGGCTTTCAAGAACGCCCAGGCGCCTGATACACCGCGCCTGTACGCCCTTGATCTGTAT
CTCGAGGATGGCGTGCTGCCGCAGCCACCCTGA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13394.56 Da        Isoelectric Point: 10.8344

>AT38430 WP_203791757.1 NZ_AP024354:1464415-1464786 [Pseudomonas alcaligenes]
MSALSKPGVDAGTVLLKALLNSREQLGLTQQELAAIVGVNRSAISRWSDSGGLRPESKTGELALLLIRAYRALFALFGGN
LQDMRHFLRTENRHLAGVPLQQMGQVQGLVRVVEYLDAIRGKV

Download         Length: 372 bp

>AT38430 NZ_AP024354:1464415-1464786 [Pseudomonas alcaligenes]
ATGAGCGCACTCAGCAAGCCAGGTGTCGATGCCGGCACCGTCCTGCTCAAGGCCCTGCTCAACAGCCGTGAGCAGCTGGG
CCTGACCCAGCAGGAGCTGGCGGCGATAGTCGGCGTCAACCGTTCCGCCATCAGTCGCTGGAGCGACAGCGGCGGCCTGC
GTCCGGAGAGCAAGACCGGTGAGCTGGCCTTGCTGCTGATCCGCGCCTATCGCGCCCTGTTCGCCCTGTTCGGCGGCAAT
CTGCAGGACATGCGGCATTTCCTGCGCACCGAGAATCGCCATCTGGCCGGTGTGCCCTTGCAGCAGATGGGGCAGGTACA
GGGGCTGGTGCGGGTGGTCGAGTACCTGGACGCCATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References