38429

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1021026..1022618 Replicon chromosome
Accession NZ_AP024354
Organism Pseudomonas alcaligenes strain KAM426

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag JUH08_RS04765 Protein ID WP_088177214.1
Coordinates 1021026..1022351 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JUH08_RS04770 Protein ID WP_088177211.1
Coordinates 1022352..1022618 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JUH08_RS04730 1016244..1016804 + 561 WP_203790996.1 zeta toxin family protein -
JUH08_RS04735 1016816..1017978 + 1163 WP_128688142.1 IS3 family transposase -
JUH08_RS04740 1018262..1018822 - 561 WP_203790998.1 hypothetical protein -
JUH08_RS04745 1018908..1019123 - 216 WP_203791000.1 hypothetical protein -
JUH08_RS04750 1019395..1019601 + 207 WP_203791002.1 hypothetical protein -
JUH08_RS04755 1019944..1020447 - 504 WP_088177213.1 type II toxin-antitoxin system YhaV family toxin -
JUH08_RS04760 1020444..1020770 - 327 WP_088177212.1 type II toxin-antitoxin system PrlF family antitoxin -
JUH08_RS04765 1021026..1022351 + 1326 WP_088177214.1 HipA domain-containing protein Toxin
JUH08_RS04770 1022352..1022618 + 267 WP_088177211.1 helix-turn-helix domain-containing protein Antitoxin
JUH08_RS04775 1022666..1022869 - 204 WP_088177210.1 hypothetical protein -
JUH08_RS04780 1022955..1023086 - 132 WP_143492042.1 DUF4113 domain-containing protein -
JUH08_RS04785 1023650..1024630 - 981 Protein_937 IS5-like element ISPa16 family transposase -
JUH08_RS04790 1025746..1026459 - 714 WP_203791004.1 hypothetical protein -
JUH08_RS04795 1026744..1027298 + 555 WP_203791006.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - xcpA/pilD / pilC / pilB 947520..1076676 129156


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-378)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 49244.75 Da        Isoelectric Point: 5.0363

>T38429 WP_088177214.1 NZ_AP024354:1021026-1022351 [Pseudomonas alcaligenes]
MHNLTLQVFTNGQWRNAMELRFEQPEEGLEGACAYGYQQGYLVDSLESVGSRLNVAVSAAYPLGWDSWRESKAPAFLFDI
LPSGAARRFLLKRLGGERPEGLNLDLYLLGRCTPAPIGNLRIKESVEAIAGSPMLGFTRYEVIRRDARFLEYAYEQGAAI
GGATGAGGEAPKLLLTEDRHGALHPDAVLPDEEAAQHWFVKFARNKAAQTDQDILRSEYCFYRAIQQLGMDTIAADGLAL
EEGNKPSLWMHRFDREISSAGVGRTAVESMYSLSGVTEAGSYMLHSQVLRNLVELWQAVGQGQQVEDLVFEYMRRDLLNQ
ILGNSDNHGRNTSIIRSEQGVRLAPIYDLAPMVMDEEGVTRTTKWPKHIELAGEVNWRVACAEAAEWVDPDELFQRLRAA
AQEFQALPDLLNAEGLPASTMNHPRIALRNLRQRLVQWGLI

Download         Length: 1326 bp

>T38429 NZ_AP024354:1021026-1022351 [Pseudomonas alcaligenes]
ATGCACAACCTCACTCTCCAGGTTTTTACGAATGGCCAGTGGCGCAATGCCATGGAGCTCCGCTTCGAGCAGCCCGAGGA
AGGGCTGGAGGGGGCTTGTGCTTATGGCTACCAGCAGGGCTATCTGGTTGACTCCCTGGAGTCTGTCGGCAGTCGGCTGA
ATGTGGCTGTCAGCGCAGCTTACCCTCTCGGCTGGGACTCCTGGCGAGAGAGTAAGGCACCAGCGTTTCTCTTCGACATC
CTGCCATCAGGCGCTGCCAGACGCTTTCTACTGAAGCGCTTGGGAGGCGAGCGACCTGAGGGCCTCAACCTGGATCTCTA
CCTCTTGGGGCGTTGTACGCCCGCACCGATTGGCAATCTGCGTATCAAGGAATCTGTCGAGGCGATTGCGGGCAGCCCTA
TGCTGGGCTTCACGCGCTATGAGGTTATTCGTCGGGACGCTCGCTTCCTTGAATACGCTTATGAGCAGGGGGCAGCCATA
GGTGGTGCGACTGGGGCTGGTGGCGAGGCTCCCAAGTTGCTGTTGACGGAGGATCGCCATGGTGCGTTGCACCCGGATGC
AGTACTGCCTGACGAAGAGGCTGCTCAGCACTGGTTTGTGAAGTTTGCGCGCAACAAAGCCGCGCAGACGGATCAGGACA
TCCTTCGCAGCGAGTACTGTTTTTATCGCGCCATCCAGCAGTTAGGGATGGATACCATTGCGGCTGACGGGCTGGCGTTG
GAAGAGGGCAATAAGCCCAGTCTCTGGATGCACCGCTTTGATCGGGAGATCAGCTCTGCAGGTGTTGGGCGAACGGCAGT
GGAGTCCATGTACTCGCTATCCGGCGTGACCGAGGCGGGGAGCTACATGCTGCACTCCCAGGTGCTGCGAAACCTGGTCG
AGCTATGGCAGGCCGTTGGGCAGGGACAGCAGGTTGAGGATCTGGTGTTCGAATACATGCGGCGCGATCTGCTGAACCAG
ATTCTTGGTAACTCAGATAACCACGGACGCAACACCTCCATTATTCGCTCTGAGCAAGGTGTGCGGCTGGCACCGATCTA
TGACCTGGCCCCCATGGTCATGGATGAGGAAGGGGTCACGCGCACGACGAAATGGCCAAAGCACATCGAGCTGGCAGGAG
AGGTCAACTGGAGAGTCGCCTGTGCCGAGGCGGCAGAATGGGTAGATCCTGATGAGCTGTTCCAGAGATTGAGAGCCGCA
GCGCAGGAGTTCCAGGCGCTACCTGATTTGCTGAATGCAGAAGGGCTTCCCGCTTCAACCATGAACCACCCACGTATCGC
GCTGAGAAACCTTCGGCAGCGCCTGGTCCAGTGGGGGCTGATCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9903.53 Da        Isoelectric Point: 10.9502

>AT38429 WP_088177211.1 NZ_AP024354:1022352-1022618 [Pseudomonas alcaligenes]
MDILERNRVLNELQQQLASGEITIGAAVRRLRKEVTGLQQARFAQMCKLSLRALRQLELDESNPTVQTLNSVFNPFGMQV
GIVPKAPR

Download         Length: 267 bp

>AT38429 NZ_AP024354:1022352-1022618 [Pseudomonas alcaligenes]
ATGGATATTCTTGAGCGCAATCGAGTTTTGAATGAACTGCAGCAGCAGTTGGCTTCTGGTGAGATCACTATTGGGGCGGC
CGTTCGGCGTCTGCGCAAGGAGGTGACGGGGCTGCAGCAGGCCAGATTCGCACAGATGTGCAAGCTGTCATTACGCGCTT
TGCGGCAGCTAGAGCTTGATGAGAGCAACCCGACTGTTCAGACGCTGAACAGTGTCTTCAACCCGTTTGGTATGCAGGTT
GGCATCGTGCCGAAGGCTCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References