Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4361446..4362227 Replicon chromosome
Accession NZ_AP024347
Organism Salmonella enterica strain SEOhiM1593

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3V5VMY0
Locus tag QMN54_RS21330 Protein ID WP_023258552.1
Coordinates 4361446..4361937 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag QMN54_RS21335 Protein ID WP_001110450.1
Coordinates 4361934..4362227 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMN54_RS21305 (SAML1593_40910) 4358326..4359156 - 831 WP_023259008.1 fimbria/pilus periplasmic chaperone -
QMN54_RS21310 (SAML1593_40920) 4359358..4359663 - 306 WP_000370555.1 PapB/FocB family fimbrial expression transcriptional regulator -
QMN54_RS21315 4360196..4360339 + 144 Protein_4169 transposase -
QMN54_RS21320 (SAML1593_40930) 4360356..4360702 + 347 Protein_4170 Rpn family recombination-promoting nuclease/putative transposase -
QMN54_RS21325 4360983..4361231 - 249 Protein_4171 IS481 family transposase -
QMN54_RS21330 (SAML1593_40950) 4361446..4361937 - 492 WP_023258552.1 GNAT family N-acetyltransferase Toxin
QMN54_RS21335 (SAML1593_40960) 4361934..4362227 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
QMN54_RS21340 (SAML1593_40970) 4362544..4362766 + 223 Protein_4174 hypothetical protein -
QMN54_RS21345 (SAML1593_40980) 4363032..4363907 + 876 WP_000921674.1 AraC family transcriptional regulator -
QMN54_RS21350 (SAML1593_40990) 4363904..4364191 + 288 WP_001269916.1 transcriptional regulator RtsB -
QMN54_RS21355 (SAML1593_41000) 4364214..4364429 + 216 WP_001595136.1 hypothetical protein -
QMN54_RS21360 4364437..4364704 + 268 Protein_4178 hypothetical protein -
QMN54_RS21365 (SAML1593_41010) 4365000..4365905 - 906 WP_001268206.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4349947..4364191 14244


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17636.41 Da        Isoelectric Point: 7.2655

>T38424 WP_023258552.1 NZ_AP024347:c4361937-4361446 [Salmonella enterica]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T38424 NZ_AP024347:c4361937-4361446 [Salmonella enterica]
ATGATCTCCTCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAGCGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGAACCATCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT38424 WP_001110450.1 NZ_AP024347:c4362227-4361934 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT38424 NZ_AP024347:c4362227-4361934 [Salmonella enterica]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCCTATCAGGAATTTCTGGCTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VMY0

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References