Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4224578..4225094 Replicon chromosome
Accession NZ_AP024347
Organism Salmonella enterica strain SEOhiM1593

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag QMN54_RS20605 Protein ID WP_000220577.1
Coordinates 4224578..4224862 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag QMN54_RS20610 Protein ID WP_000212724.1
Coordinates 4224852..4225094 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMN54_RS20590 (SAML1593_39550) 4219790..4221442 + 1653 WP_023258527.1 alpha,alpha-phosphotrehalase -
QMN54_RS20595 (SAML1593_39560) 4221851..4223989 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
QMN54_RS20600 (SAML1593_39570) 4224110..4224574 + 465 WP_020898293.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QMN54_RS20605 (SAML1593_39580) 4224578..4224862 - 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QMN54_RS20610 (SAML1593_39590) 4224852..4225094 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QMN54_RS20615 (SAML1593_39600) 4225172..4227085 - 1914 WP_282027244.1 BglG family transcription antiterminator -
QMN54_RS20620 (SAML1593_39610) 4227102..4227842 - 741 WP_023258525.1 KDGP aldolase family protein -
QMN54_RS20625 (SAML1593_39620) 4227839..4228957 - 1119 WP_001139178.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
QMN54_RS20630 (SAML1593_39630) 4228941..4230074 - 1134 WP_023258524.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T38423 WP_000220577.1 NZ_AP024347:c4224862-4224578 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T38423 NZ_AP024347:c4224862-4224578 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT38423 WP_000212724.1 NZ_AP024347:c4225094-4224852 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT38423 NZ_AP024347:c4225094-4224852 [Salmonella enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References