38422

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4183243..4183793 Replicon chromosome
Accession NZ_AP024347
Organism Salmonella enterica strain SEOhiM1593

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag QMN54_RS20400 Protein ID WP_001199743.1
Coordinates 4183243..4183551 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7RP97
Locus tag QMN54_RS20405 Protein ID WP_001118105.1
Coordinates 4183554..4183793 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMN54_RS20380 (SAML1593_39160) 4178583..4179494 + 912 WP_052940712.1 zincin-like metallopeptidase domain-containing protein -
QMN54_RS20385 (SAML1593_39170) 4179600..4180055 + 456 WP_024150363.1 NUDIX domain-containing protein -
QMN54_RS20390 (SAML1593_39180) 4180346..4181965 + 1620 WP_023258423.1 MobH family relaxase -
QMN54_RS20395 (SAML1593_39190) 4181955..4182881 + 927 WP_023258424.1 site-specific integrase -
QMN54_RS20400 (SAML1593_39200) 4183243..4183551 - 309 WP_001199743.1 CcdB family protein Toxin
QMN54_RS20405 (SAML1593_39210) 4183554..4183793 - 240 WP_001118105.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
QMN54_RS20410 (SAML1593_39220) 4183902..4184150 - 249 WP_000168385.1 ribbon-helix-helix domain-containing protein -
QMN54_RS20415 (SAML1593_39230) 4184227..4184535 - 309 Protein_3994 DUF4942 domain-containing protein -
QMN54_RS20420 4184555..4185532 - 978 Protein_3995 IS630 family transposase -
QMN54_RS20430 (SAML1593_39260) 4186290..4187309 + 1020 WP_000152563.1 NAD(P)-dependent alcohol dehydrogenase -
QMN54_RS20435 (SAML1593_39270) 4187337..4187867 - 531 WP_000896756.1 gluconokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4184879..4185487 608


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T38422 WP_001199743.1 NZ_AP024347:c4183551-4183243 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T38422 NZ_AP024347:c4183551-4183243 [Salmonella enterica]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGTCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8719.90 Da        Isoelectric Point: 6.4633

>AT38422 WP_001118105.1 NZ_AP024347:c4183793-4183554 [Salmonella enterica]
MPGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT38422 NZ_AP024347:c4183793-4183554 [Salmonella enterica]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H9SZK8

References