Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4150832..4152470 Replicon chromosome
Accession NZ_AP024347
Organism Salmonella enterica strain SEOhiM1593

Toxin (Protein)


Gene name hipA Uniprot ID A0A3W0PFL5
Locus tag QMN54_RS20235 Protein ID WP_001255025.1
Coordinates 4150832..4152160 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B5F4A7
Locus tag QMN54_RS20240 Protein ID WP_001099274.1
Coordinates 4152165..4152470 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMN54_RS20225 (SAML1593_38840) 4147334..4149418 + 2085 WP_001523657.1 protease Lon-related BREX system protein BrxL -
QMN54_RS20230 (SAML1593_38850) 4149531..4150520 - 990 WP_077905616.1 restriction endonuclease -
QMN54_RS20235 (SAML1593_38860) 4150832..4152160 - 1329 WP_001255025.1 type II toxin-antitoxin system HipA family toxin Toxin
QMN54_RS20240 (SAML1593_38870) 4152165..4152470 - 306 WP_001099274.1 helix-turn-helix transcriptional regulator Antitoxin
QMN54_RS20245 (SAML1593_38880) 4153217..4153687 + 471 WP_023258572.1 hypothetical protein -
QMN54_RS20250 (SAML1593_38890) 4154034..4154732 + 699 WP_023258571.1 TIGR03761 family integrating conjugative element protein -
QMN54_RS20255 (SAML1593_38900) 4154722..4155210 + 489 WP_023258570.1 DUF3158 family protein -
QMN54_RS20260 (SAML1593_38920) 4155776..4156192 + 417 WP_023258569.1 STY4534 family ICE replication protein -
QMN54_RS20265 (SAML1593_38930) 4156422..4156772 + 351 WP_023258568.1 hypothetical protein -
QMN54_RS20270 (SAML1593_38940) 4156765..4157331 + 567 WP_023258567.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 50835.64 Da        Isoelectric Point: 5.1343

>T38421 WP_001255025.1 NZ_AP024347:c4152160-4150832 [Salmonella enterica]
MRRTQQRLSIWMNGIRVGFWEKARGEDLLQYLPEWIIDEQGRPLSLSLPFTPGNQLWRGNVVRDYFDNLLPDSESIRRRL
AVRYQAESLEPFDLLAELGRDCVGAIQLLNVDEEPTDLFSVNYRPLSEADIATTLRNTTAISLPGRQDETDDLRLSIAGA
QEKTALLWHEERWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLLLEHYGIPVAKTQIAQFEDQKALVVERF
DRRWSGDRQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMEILSHSDQAEQDKEQFFRAQIIFWLMAATDGHAKNFS
IAIEPQSRYHLTPLYDLLSAWPVIGHGNNQISWQRCKQAMAVRGSSNYYHIYRIQRRHWINHGELTGLGRRQVESMMDDI
ISSTPEVIERVSALLPESFPPELAECIFEGMRQQCRRLAGRE

Download         Length: 1329 bp

>T38421 NZ_AP024347:c4152160-4150832 [Salmonella enterica]
ATGCGTCGAACACAGCAGCGTTTATCAATATGGATGAATGGAATCCGGGTCGGATTCTGGGAGAAGGCCAGAGGCGAGGA
TTTATTACAATACCTTCCAGAATGGATAATTGATGAACAGGGAAGACCTTTATCGCTTTCTTTGCCTTTCACTCCAGGTA
ATCAGCTTTGGCGTGGTAATGTTGTTCGTGACTATTTTGATAATTTATTGCCTGACAGCGAAAGTATACGCAGACGTTTA
GCCGTGCGTTACCAGGCTGAAAGCCTTGAGCCTTTTGATCTATTGGCTGAGCTGGGAAGAGACTGCGTTGGTGCAATACA
GTTACTGAATGTTGATGAAGAGCCCACAGATTTATTTTCCGTAAATTATCGCCCACTTTCTGAAGCTGATATCGCAACTA
CATTGCGTAATACTACGGCGATATCGTTGCCTGGTCGGCAGGACGAAACTGACGATTTGCGATTATCAATTGCCGGCGCG
CAGGAAAAAACGGCTTTATTGTGGCATGAAGAACGATGGTGTTTACCTGAAGGTAATACCCCAACAACGCATATCTTCAA
ACTACCGCTTGGGTTGGTTGGGAACATGCAAGCGGATATGAGTACATCGGTTGAAAATGAATGGCTGTGTTCTTTGCTTC
TTGAGCACTACGGGATCCCTGTAGCAAAAACACAGATTGCGCAGTTTGAGGATCAGAAGGCATTAGTAGTTGAGCGTTTC
GACAGAAGATGGTCAGGCGATCGGCAATGGATCATTCGTTTGCCACAAGAGGATATGTGTCAGGCTTTAGGTGTTTCTCC
GTTACGAAAATACCAGTCTGATGGTGGGCCGGGTATTTCCGATATTATGGAAATACTGAGTCATTCAGATCAGGCTGAGC
AGGACAAAGAGCAGTTCTTCAGGGCGCAAATTATTTTCTGGTTGATGGCTGCTACTGACGGCCATGCCAAAAATTTCAGT
ATCGCTATTGAGCCACAAAGTCGTTACCACCTTACGCCTCTTTACGATCTTTTATCAGCATGGCCGGTAATTGGTCATGG
TAATAATCAGATTTCCTGGCAAAGATGCAAACAGGCAATGGCTGTTCGCGGTAGCAGTAATTATTACCACATTTATAGAA
TTCAACGGCGGCATTGGATCAATCATGGTGAATTAACCGGATTGGGAAGGCGACAAGTTGAGTCCATGATGGATGACATT
ATATCCAGTACGCCAGAAGTCATTGAGCGTGTATCTGCGTTGCTTCCAGAGTCGTTTCCACCTGAGCTTGCTGAGTGTAT
TTTTGAAGGTATGCGGCAGCAGTGTAGGCGTTTGGCTGGAAGGGAATAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11362.04 Da        Isoelectric Point: 9.7765

>AT38421 WP_001099274.1 NZ_AP024347:c4152470-4152165 [Salmonella enterica]
MNTVYPLKTLNQIRPLLIGFRKANGLTQKEVSERLGVTQQTYARLEANPASASMERLFRVFTVLGVEMVLSSGPQILSSM
SSSTMEESEQQIDSPARREKW

Download         Length: 306 bp

>AT38421 NZ_AP024347:c4152470-4152165 [Salmonella enterica]
ATGAATACTGTTTATCCGTTGAAAACTTTGAATCAAATTCGTCCATTGCTGATTGGCTTTCGCAAGGCTAATGGACTGAC
ACAAAAGGAAGTTTCTGAAAGGTTAGGAGTAACTCAGCAAACTTATGCCCGACTGGAAGCGAATCCAGCCAGTGCCAGTA
TGGAGCGACTATTCAGGGTATTTACCGTGCTGGGTGTAGAAATGGTACTCTCTTCTGGGCCACAGATACTTTCTTCGATG
TCATCCTCAACAATGGAAGAGTCAGAACAGCAAATAGATTCACCTGCCAGACGGGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3W0PFL5

Antitoxin

Source ID Structure
AlphaFold DB A0A3V5VUF2

References