Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3506145..3506765 Replicon chromosome
Accession NZ_AP024347
Organism Salmonella enterica strain SEOhiM1593

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag QMN54_RS17270 Protein ID WP_001280991.1
Coordinates 3506547..3506765 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag QMN54_RS17265 Protein ID WP_000344807.1
Coordinates 3506145..3506519 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMN54_RS17255 (SAML1593_33160) 3501284..3502477 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QMN54_RS17260 (SAML1593_33170) 3502500..3505649 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
QMN54_RS17265 (SAML1593_33180) 3506145..3506519 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
QMN54_RS17270 (SAML1593_33190) 3506547..3506765 + 219 WP_001280991.1 HHA domain-containing protein Toxin
QMN54_RS17275 (SAML1593_33200) 3506944..3507495 + 552 WP_023258996.1 maltose O-acetyltransferase -
QMN54_RS17280 (SAML1593_33210) 3507613..3508083 + 471 WP_000136183.1 YlaC family protein -
QMN54_RS17285 3508139..3508279 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
QMN54_RS17290 (SAML1593_33220) 3508285..3508545 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
QMN54_RS17295 (SAML1593_33230) 3508770..3510320 + 1551 WP_023258997.1 EAL domain-containing protein -
QMN54_RS17305 (SAML1593_33240) 3510551..3510940 + 390 WP_000961285.1 MGMT family protein -
QMN54_RS17310 (SAML1593_33250) 3510973..3511542 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T38420 WP_001280991.1 NZ_AP024347:3506547-3506765 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T38420 NZ_AP024347:3506547-3506765 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT38420 WP_000344807.1 NZ_AP024347:3506145-3506519 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT38420 NZ_AP024347:3506145-3506519 [Salmonella enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References