38419

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2475231..2475753 Replicon chromosome
Accession NZ_AP024347
Organism Salmonella enterica strain SEOhiM1593

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag QMN54_RS12040 Protein ID WP_000221343.1
Coordinates 2475469..2475753 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag QMN54_RS12035 Protein ID WP_000885424.1
Coordinates 2475231..2475479 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMN54_RS12005 (SAML1593_23040) 2470249..2471502 + 1254 WP_023258252.1 nucleoside permease -
QMN54_RS12010 2471704..2472228 - 525 WP_023258253.1 NUDIX domain-containing protein -
QMN54_RS12015 (SAML1593_23060) 2472213..2473259 - 1047 WP_232092124.1 LacI family DNA-binding transcriptional regulator -
QMN54_RS12020 2473593..2473709 - 117 Protein_2350 IS110 family transposase -
QMN54_RS12025 (SAML1593_23070) 2474074..2474463 + 390 WP_023258255.1 hypothetical protein -
QMN54_RS12030 2474466..2474819 + 354 WP_000418733.1 hypothetical protein -
QMN54_RS12035 (SAML1593_23080) 2475231..2475479 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QMN54_RS12040 (SAML1593_23090) 2475469..2475753 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QMN54_RS12045 (SAML1593_23100) 2475924..2476313 + 390 WP_023258256.1 RidA family protein -
QMN54_RS12050 (SAML1593_23110) 2476365..2477444 - 1080 WP_052940657.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
QMN54_RS12055 (SAML1593_23120) 2477637..2478125 - 489 WP_023258342.1 MarR family winged helix-turn-helix transcriptional regulator -
QMN54_RS12060 (SAML1593_23130) 2478170..2479678 + 1509 WP_023258341.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2465051..2482535 17484


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T38419 WP_000221343.1 NZ_AP024347:2475469-2475753 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T38419 NZ_AP024347:2475469-2475753 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGTTACGGGAACGTCTTGAAAACCCTCGGGTTCCGGCTTCGCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGACGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT38419 WP_000885424.1 NZ_AP024347:2475231-2475479 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT38419 NZ_AP024347:2475231-2475479 [Salmonella enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References