38410

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1105643..1106457 Replicon chromosome
Accession NZ_AP024347
Organism Salmonella enterica strain SEOhiM1593

Toxin (Protein)


Gene name TacT3 Uniprot ID M7RPS8
Locus tag QMN54_RS05335 Protein ID WP_000971649.1
Coordinates 1105643..1106170 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag QMN54_RS05340 Protein ID WP_000855694.1
Coordinates 1106167..1106457 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMN54_RS05295 1100715..1100837 + 123 Protein_1039 cytoplasmic protein -
QMN54_RS05300 1100907..1102017 + 1111 WP_103036012.1 IS3 family transposase -
QMN54_RS05305 1102033..1102341 + 309 Protein_1041 cytoplasmic protein -
QMN54_RS05310 1102529..1102755 + 227 Protein_1042 hypothetical protein -
QMN54_RS05315 (SAML1593_10360) 1102912..1103580 + 669 WP_000445914.1 hypothetical protein -
QMN54_RS05320 (SAML1593_10370) 1103607..1104101 + 495 WP_023258825.1 hypothetical protein -
QMN54_RS05325 (SAML1593_10380) 1104272..1104928 - 657 WP_023258826.1 protein-serine/threonine phosphatase -
QMN54_RS05330 1105161..1105570 + 410 Protein_1046 IS5/IS1182 family transposase -
QMN54_RS05335 (SAML1593_10400) 1105643..1106170 - 528 WP_000971649.1 GNAT family N-acetyltransferase Toxin
QMN54_RS05340 (SAML1593_10410) 1106167..1106457 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
QMN54_RS05345 1106727..1106905 - 179 Protein_1049 IS3 family transposase -
QMN54_RS05350 (SAML1593_10420) 1107146..1107472 + 327 WP_052940661.1 hypothetical protein -
QMN54_RS05355 (SAML1593_10430) 1107745..1108092 - 348 WP_001669174.1 DUF1493 family protein -
QMN54_RS05360 (SAML1593_10440) 1108077..1108526 - 450 WP_000381612.1 membrane protein -
QMN54_RS05365 (SAML1593_10450) 1108958..1109401 - 444 WP_052940662.1 SPI-1 type III secretion system invasion lipoprotein InvH -
QMN54_RS05370 (SAML1593_10460) 1109859..1110509 + 651 WP_001728903.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 1093095..1115822 22727


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19026.88 Da        Isoelectric Point: 9.3905

>T38410 WP_000971649.1 NZ_AP024347:c1106170-1105643 [Salmonella enterica]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T38410 NZ_AP024347:c1106170-1105643 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACTACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT38410 WP_000855694.1 NZ_AP024347:c1106457-1106167 [Salmonella enterica]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT38410 NZ_AP024347:c1106457-1106167 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGACTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VVF5

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References