Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 938249..938874 Replicon chromosome
Accession NZ_AP024347
Organism Salmonella enterica strain SEOhiM1593

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QMN54_RS04590 Protein ID WP_000911337.1
Coordinates 938476..938874 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag QMN54_RS04585 Protein ID WP_000557549.1
Coordinates 938249..938476 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QMN54_RS04555 (SAML1593_08880) 933312..934410 + 1099 WP_010989230.1 peptide chain release factor 2 -
QMN54_RS04560 (SAML1593_08890) 934420..935937 + 1518 WP_000003339.1 lysine--tRNA ligase -
QMN54_RS04565 (SAML1593_08900) 936013..936558 - 546 WP_023258155.1 isopentenyl-diphosphate Delta-isomerase -
QMN54_RS04570 (SAML1593_08910) 936823..937581 + 759 WP_000244328.1 amidase activator ActS -
QMN54_RS04580 937827..938010 - 184 Protein_898 hypothetical protein -
QMN54_RS04585 (SAML1593_08920) 938249..938476 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
QMN54_RS04590 (SAML1593_08930) 938476..938874 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
QMN54_RS04595 (SAML1593_08940) 939681..940217 + 537 WP_001038505.1 STM3031 family outer membrane protein -
QMN54_RS04600 (SAML1593_08950) 940264..940896 + 633 WP_000835265.1 YfdX family protein -
QMN54_RS04605 (SAML1593_08960) 941615..942202 + 588 WP_024150393.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T38409 WP_000911337.1 NZ_AP024347:938476-938874 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T38409 NZ_AP024347:938476-938874 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACTTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT38409 WP_000557549.1 NZ_AP024347:938249-938476 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT38409 NZ_AP024347:938249-938476 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGCACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References