38404

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4152353..4153008 Replicon chromosome
Accession NZ_AP024342
Organism Pseudomonas sp. Eqa60

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KI242_RS18790 Protein ID WP_053159224.1
Coordinates 4152353..4152532 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KI242_RS18795 Protein ID WP_053159226.1
Coordinates 4152583..4153008 (+) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI242_RS18760 (PEQA60_37490) 4147711..4147986 + 276 WP_011061856.1 peptidylprolyl isomerase -
KI242_RS18765 (PEQA60_37500) 4148193..4149101 - 909 WP_212805428.1 sugar kinase -
KI242_RS18770 (PEQA60_37510) 4149245..4150462 - 1218 WP_015636023.1 amino acid deaminase -
KI242_RS18775 (PEQA60_37520) 4150510..4151274 - 765 WP_212805429.1 IclR family transcriptional regulator -
KI242_RS18780 (PEQA60_37530) 4151407..4151796 - 390 WP_011061860.1 RidA family protein -
KI242_RS18785 (PEQA60_37540) 4152115..4152264 + 150 WP_155494419.1 hypothetical protein -
KI242_RS18790 (PEQA60_37550) 4152353..4152532 + 180 WP_053159224.1 type II toxin-antitoxin system HicA family toxin Toxin
KI242_RS18795 (PEQA60_37560) 4152583..4153008 + 426 WP_053159226.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KI242_RS18800 (PEQA60_37570) 4153096..4153641 - 546 WP_053159228.1 hypothetical protein -
KI242_RS18805 (PEQA60_37580) 4153828..4155261 - 1434 WP_019095389.1 RtcB family protein -
KI242_RS18810 (PEQA60_37590) 4155769..4156785 - 1017 WP_077934398.1 fimbrial protein -
KI242_RS18815 (PEQA60_37600) 4157092..4157664 + 573 WP_019095391.1 type 1 glutamine amidotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6632.67 Da        Isoelectric Point: 11.1475

>T38404 WP_053159224.1 NZ_AP024342:4152353-4152532 [Pseudomonas sp. Eqa60]
MKFSEFRRWLKAQGVVFEAGKGSHFKVTAPNGNKTTFADHGSKEMPEPTRKAIIRQLGL

Download         Length: 180 bp

>T38404 NZ_AP024342:4152353-4152532 [Pseudomonas sp. Eqa60]
ATGAAATTCAGCGAATTCAGACGGTGGTTGAAAGCTCAAGGCGTGGTCTTCGAGGCCGGTAAAGGCAGCCACTTCAAAGT
CACGGCCCCAAACGGCAACAAGACCACCTTCGCGGATCACGGCAGCAAGGAAATGCCCGAACCCACCCGCAAGGCAATCA
TCAGGCAATTGGGGCTCTAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15743.06 Da        Isoelectric Point: 4.7790

>AT38404 WP_053159226.1 NZ_AP024342:4152583-4153008 [Pseudomonas sp. Eqa60]
MYDYAIRFEQDRAPGVAVFCRDLPELNSFGDDPEHAINQAIDALETTLSLYVDQRRAIPPASEPLPGEQVIHLPMVTVAK
IALWNTMMERDMRKADLCRLLGIHQAQGDRLVDFLHSSKMEQLENALAALGKRLAVSVEAA

Download         Length: 426 bp

>AT38404 NZ_AP024342:4152583-4153008 [Pseudomonas sp. Eqa60]
ATGTACGACTACGCCATTCGCTTCGAGCAAGACCGTGCACCGGGAGTGGCGGTCTTCTGCCGCGATCTGCCCGAACTCAA
TAGCTTTGGCGATGATCCTGAGCACGCCATCAACCAGGCCATCGACGCGCTCGAAACCACGCTGTCCCTTTACGTCGACC
AGCGCCGCGCCATTCCCCCAGCCTCTGAGCCGCTACCAGGGGAACAGGTCATTCATTTGCCAATGGTGACCGTGGCCAAG
ATAGCGCTGTGGAACACGATGATGGAGCGGGACATGCGCAAGGCCGATCTATGCCGACTGCTCGGAATCCACCAGGCCCA
GGGAGATCGCCTGGTGGACTTTCTACACAGCTCCAAAATGGAACAGCTGGAAAATGCCCTCGCAGCCCTAGGTAAACGTC
TTGCAGTATCAGTGGAGGCGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References