Detailed information of TA system TA038401

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2550279..2550898
• Replicon: chromosome
• Accession: NZ_AP024342
• Organism: Pseudomonas sp. Eqa60

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KI242_RS11670
• Protein ID: WP_041752740.1
• Coordinates: 2550716..2550898 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KI242_RS11665
• Protein ID: WP_182999911.1
• Coordinates: 2550279..2550680 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI242_RS11635 (PEQA60_23110)	2545731..2546078	-	348	WP_015634975.1	metalloregulator ArsR/SmtB family transcription factor	-
KI242_RS11640 (PEQA60_23120)	2546309..2546863	+	555	WP_212806165.1	hypothetical protein	-
KI242_RS11645 (PEQA60_23130)	2547109..2547540	-	432	WP_011060488.1	carboxymuconolactone decarboxylase family protein	-
KI242_RS11650 (PEQA60_23140)	2547569..2548189	-	621	WP_103408227.1	NAD(P)H-dependent oxidoreductase	-
KI242_RS11655 (PEQA60_23150)	2548186..2548632	-	447	WP_123430368.1	GNAT family N-acetyltransferase	-
KI242_RS11660 (PEQA60_23160)	2548720..2550123	+	1404	WP_212806166.1	PLP-dependent aminotransferase family protein	-
KI242_RS11665 (PEQA60_23170)	2550279..2550680	-	402	WP_182999911.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KI242_RS11670	2550716..2550898	-	183	WP_041752740.1	type II toxin-antitoxin system HicA family toxin	Toxin
KI242_RS11675	2550948..2551148	+	201	WP_212806167.1	hypothetical protein	-
KI242_RS11680	2551591..2552109	+	519	WP_053150430.1	sugar O-acetyltransferase	-
KI242_RS11685 (PEQA60_23180)	2552130..2553368	+	1239	WP_041117182.1	aminotransferase class III-fold pyridoxal phosphate-dependent enzyme	-
KI242_RS11690 (PEQA60_23190)	2553346..2555133	+	1788	WP_220802792.1	1-deoxy-D-xylulose-5-phosphate synthase N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2550279..2559827	9548

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6959.13 Da
• Isoelectric Point: 10.9595

>T38401 WP_041752740.1 NZ_AP024342:c2550898-2550716 [Pseudomonas sp. Eqa60]
VQSRQLIKELEATGWVLERVTESHHLFKHPYRPNTVPAPHPKKDLPRGTVRAIRKLAELI

Nucleotide

• Length: 183 bp

>T38401 NZ_AP024342:c2550898-2550716 [Pseudomonas sp. Eqa60]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCACAGGATGGGTGCTGGAGCGAGTCACCGAAAGCCATCATCTGTT
CAAGCATCCTTACAGGCCCAACACCGTTCCGGCGCCTCACCCGAAGAAGGATCTGCCACGGGGTACGGTCAGGGCCATCA
GAAAACTGGCTGAACTGATCTAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14610.67 Da
• Isoelectric Point: 5.5512

>AT38401 WP_182999911.1 NZ_AP024342:c2550680-2550279 [Pseudomonas sp. Eqa60]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFETAYSAAIEIAHVMLEELARAGHAIPLPSPTRKHRANPEFAGMGWGM
LEIDITPYLGKTEKVNVTLPGYVIQQIDRFVREHNIKSRSSFLADAALEKLGR

Nucleotide

• Length: 402 bp

>AT38401 NZ_AP024342:c2550680-2550279 [Pseudomonas sp. Eqa60]
GTGCAATATCCCATCTGCATCGAATGGGGCGACGAACACACCGCCACCGGCATCCAGATTCCTGATATTCCCGGCGCAGT
CACCGCCGGCGACACCTTCGAAACCGCCTACAGCGCCGCCATCGAGATTGCCCACGTCATGCTCGAAGAGCTGGCCCGAG
CGGGGCACGCCATCCCCCTGCCCTCTCCCACCCGCAAGCACCGCGCCAACCCCGAGTTCGCGGGCATGGGCTGGGGCATG
CTGGAGATCGACATCACGCCTTACCTGGGCAAGACCGAAAAGGTCAACGTGACCCTGCCGGGTTATGTCATCCAGCAAAT
CGACCGCTTTGTCCGCGAGCACAACATCAAGAGCCGTTCGTCCTTCCTGGCCGATGCCGCGCTGGAAAAGCTCGGACGCT
GA